Analytical Data
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Gene name
NUDT4
- Application
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Alternative Names
NUDT4;DIPP2;KIAA0487;Diphosphoinositol polyphosphate phosphohydrolase 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NZJ9
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Expression Region
1-180aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMMKFKPN QTRTYDREGF KKRAACLCFR SEQEDEVLLV SSSRYPDQWI VPGGGMEPEE EPGGAAVREV YEEAGVKGKL GRLLGIFENQ DRKHRTYVYV LTVTEILEDW EDSVNIGRKR EWFKVEDAIK VLQCHKPVHA EYLEKLKLGC SPANGNSTVP SLPDNNALFV TAAQTSGLPS SVR
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Molecular Weight
23 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NUDT4, also known as Nudix hydrolase 4, is a member of the Nudix hydrolase family, which plays a crucial role in nucleotide metabolism by catalyzing the hydrolysis of various nucleoside diphosphates and related compounds. Research on NUDT4 has gained attention due to its potential involvement in cellular stress responses, regulation of nucleotide pools, and implications in various diseases, including cancer and metabolic disorders. Understanding the enzymatic activity of NUDT4 is critical for elucidating its functions in cellular processes and its potential role as a therapeutic target. Recent studies have focused on characterizing the kinetic properties of NUDT4, exploring its substrate specificity, and investigating its regulatory mechanisms. Advances in structural biology techniques, such as X-ray crystallography and cryo-electron microscopy, have provided insights into the three-dimensional structure of NUDT4, revealing how substrate binding and catalytic activity are facilitated. The ongoing research aims to further unravel the biological significance of NUDT4, particularly in relation to cellular homeostasis and signal transduction pathways. As scientists continue to explore the NUDT4 enzyme, its potential applications in biotechnology and medicine are also being explored, which could lead to novel strategies for treating diseases associated with dysregulated nucleotide metabolism.
