Cat: PA1000-2233

Recombinant Human OAZ1 Protein,His

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Analytical Data

  • 基因名

    OAZ1

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    OAZ1;OAZ;Ornithine decarboxylase antizyme 1

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    His tag N-Terminus

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    P54368

  • 表达区间

    1-228aa

  • 氨基酸序列

    MGSSHHHHHH SSGLVPRGSH MGSMVKSSLQ RILNSHCFAR EKEGDKPSAT IHASRTMPLL SLHSRGGSSS ESSRVSLHCC SNPGPGPRWC SDAPHPPLKI PGGRGNSQRD HNLSANLFYS DDRLNVTEEL TSNDKTRILN VQSRLTDAKR INWRTVLSGG SLYIEIPGGA LPEGSKDSFA VLLEFAEEQL RADHVFICFH KNREDRAALL RTFSFLGFEI VRPGHPLVPK RPDACFMAYT FERESSGEEE E

  • 分子量

    28 kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

The OAZ1 protein, or Ornithine Decarboxylase Antizyme 1, plays a crucial role in the regulation of polyamine synthesis, which is essential for cell growth and differentiation. Research has increasingly focused on OAZ1 due to its implications in various cellular processes and diseases, including cancer. In normal physiological conditions, OAZ1 acts as an inhibitor of Ornithine Decarboxylase (ODC), the enzyme responsible for the first step in polyamine biosynthesis. By regulating ODC activity, OAZ1 helps maintain cellular polyamine levels, which are vital for cellular functions such as DNA stabilization, cell proliferation, and apoptosis. Dysregulation of OAZ1 has been linked to tumorigenesis, making it a potential target for therapeutic interventions. Furthermore, OAZ1 exhibits a unique property of forming complexes with polyamines and other proteins, which underscores its multifunctional role in cellular signaling and metabolism. Recent advances in recombinant protein technology have enabled the production and characterization of OAZ1, facilitating in-depth studies of its structure, function, and interactions. Understanding the molecular mechanisms governing OAZ1 activity and its effect on polyamine metabolism may lead to novel strategies for cancer treatment and other diseases associated with altered polyamine levels. This growing body of research highlights the potential of OAZ1 not only as a biomarker for cancer progression but also as a promising target for drug development, emphasizing the importance of continued exploration into the therapeutic applications of this fascinating protein.

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IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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