Analytical Data
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Gene name
OAZ1
- Application
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Alternative Names
OAZ1;OAZ;Ornithine decarboxylase antizyme 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P54368
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Expression Region
1-228aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMVKSSLQ RILNSHCFAR EKEGDKPSAT IHASRTMPLL SLHSRGGSSS ESSRVSLHCC SNPGPGPRWC SDAPHPPLKI PGGRGNSQRD HNLSANLFYS DDRLNVTEEL TSNDKTRILN VQSRLTDAKR INWRTVLSGG SLYIEIPGGA LPEGSKDSFA VLLEFAEEQL RADHVFICFH KNREDRAALL RTFSFLGFEI VRPGHPLVPK RPDACFMAYT FERESSGEEE E
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Molecular Weight
28 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The OAZ1 protein, or Ornithine Decarboxylase Antizyme 1, plays a crucial role in the regulation of polyamine synthesis, which is essential for cell growth and differentiation. Research has increasingly focused on OAZ1 due to its implications in various cellular processes and diseases, including cancer. In normal physiological conditions, OAZ1 acts as an inhibitor of Ornithine Decarboxylase (ODC), the enzyme responsible for the first step in polyamine biosynthesis. By regulating ODC activity, OAZ1 helps maintain cellular polyamine levels, which are vital for cellular functions such as DNA stabilization, cell proliferation, and apoptosis. Dysregulation of OAZ1 has been linked to tumorigenesis, making it a potential target for therapeutic interventions. Furthermore, OAZ1 exhibits a unique property of forming complexes with polyamines and other proteins, which underscores its multifunctional role in cellular signaling and metabolism. Recent advances in recombinant protein technology have enabled the production and characterization of OAZ1, facilitating in-depth studies of its structure, function, and interactions. Understanding the molecular mechanisms governing OAZ1 activity and its effect on polyamine metabolism may lead to novel strategies for cancer treatment and other diseases associated with altered polyamine levels. This growing body of research highlights the potential of OAZ1 not only as a biomarker for cancer progression but also as a promising target for drug development, emphasizing the importance of continued exploration into the therapeutic applications of this fascinating protein.
