Analytical Data
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Gene name
S1pr2
- Application
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Alternative Names
S1pr2；EDG5；Sphingosine 1-phosphate receptor 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P52592
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Expression Region
1-352aa
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AA Sequence
MGGLYSEYLNPEKVLEHYNYTKETLDMQETTSRKVASAFIIILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGHVTLSLTPVQWFAREGSAFITLSASVFSLLAIAIERQVALAKVKLYGSDKSCRMLMLIGASWLISLILGGLPILGWNCLNQLEACSTVLPLYAKHYVLCVVTIFSVILLAIVALYVRIYFVVRSSHADVAGPQTLALLKTVTIVLGVFIICWLPAFSILLLDSTCPVRACPVLYKAHYFFAFATLNSLLNPVIYTWRSRDLRREVLRPLQCWRRGKGVTGRRGGNPGHRLLPLRSSSSLERGMHMPTSPTFLEGNTVV
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Molecular Weight
44.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
S1PR2 (Sphingosine-1-phosphate receptor 2) is a member of the sphingosine-1-phosphate receptor family, which plays a crucial role in various physiological processes, including immune response, lymphocyte trafficking, and vascular stability. Research into S1PR2 has gained attention due to its involvement in several pathophysiological conditions, such as autoimmune diseases, cardiovascular disorders, and cancer. Understanding the structure and function of the S1PR2 protein can provide insights into its signaling pathways and interactions with ligands and downstream effectors. The characterization of S1PR2 through recombinant protein techniques allows for the detailed study of its functional mechanisms, including its impact on cellular migration, proliferation, and survival. Moreover, S1PR2's potential as a therapeutic target in conditions like multiple sclerosis and cancer makes it a significant focus of drug development efforts. Advances in recombinant DNA technology facilitate the production of S1PR2 in heterologous systems, enabling researchers to investigate its pharmacological properties and discover novel modulators that can selectively influence its activity. This research not only enhances the understanding of sphingosine phosphate signaling but also paves the way for innovative treatments aimed at modulating S1PR2 activity to address a range of diseases. As such, the study of S1PR2 recombinant proteins is poised to contribute significantly to the fields of molecular biology and pharmacotherapy.
