Analytical Data
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基因名
csn
- Application
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别名
csn；MYEOV2；COP9 signalosome complex subunit 9
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
S6FZ94
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表达区间
37-278aa
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氨基酸序列
AGLNKDQKRRAEQLTSIFENGKTEIQYGYVEALDDGRGYTCGRAGFTTATGDALEVVEVYTKAVPNNKLKKYLPELRRLAKDESDDISNLKGFASAWRSLGNDKAFRAAQDKVNDSLYYQPAMKRSENAGLKTALAKAVMYDTVIQHGDGDDPDSFYALIKRTNKKMGGSPKDGTDEKKWLNKFLDVRYDDLMNPSDEDTQDEWRESVARVDVFRDIVKEKNYNLNGPIHVRSSEYGNFTIQ
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分子量
31.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Csn (Cop9 signalosome) is a multi-subunit protein complex that plays a crucial role in various cellular processes, including regulating protein degradation, cell cycle progression, and stress responses. This complex is evolutionarily conserved across eukaryotes and is known for its involvement in the modification of ubiquitin-proteasome pathways, particularly by processing and stabilizing key regulatory proteins. Recent studies have highlighted the significance of Csn in numerous biological contexts, such as development, immune responses, and tumorigenesis. The interest in Csn reorganization arises from its potential as a therapeutic target, especially in cancer, where aberrant signaling pathways often involve faulty protein degradation mechanisms. Researchers are increasingly focused on elucidating the structural and functional dynamics of Csn to better understand how its reorganization can influence cellular signaling pathways. Understanding the intricacies of Csn's role in protein homeostasis and its interactions with various substrates could pave the way for novel strategies to manipulate these pathways in disease contexts.
