Analytical Data
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基因名
PDE6D
- Application
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别名
PDE6D;PDED;Retinal rod rhodopsin-sensitive cGMP 3'.5'-cyclic phosphodiesterase subunit delta
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43924
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表达区间
1-150aa
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氨基酸序列
MSAKDERARE ILRGFKLNWM NLRDAETGKI LWQGTEDLSV PGVEHEARVP KKILKCKAVS RELNFSSTEQ MEKFRLEQKV YFKGQCLEEW FFEFGFVIPN STNTWQSLIE AAPESQMMPA SVLTGNVIIE TKFFDDDLLV STSRVRLFYV
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分子量
42 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
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Protein Description
PDE6D, also known as phosphodiesterase 6D, is a critical protein involved in the regulation of cellular signaling pathways, particularly in the phototransduction pathway in rod cells of the retina. It plays a vital role in the interaction with prenylated proteins, which are important for cellular localization and function. Research interest in PDE6D has surged due to its association with various retinal diseases and its potential role in other cellular processes, such as ciliary function, cell division, and signaling. The ability to express and purify recombinant PDE6D has opened new avenues for understanding its structural properties and interactions at the molecular level. Studies of PDE6D have also shed light on its role in diseases such as retinitis pigmentosa and other ciliopathies, where the disruption of signaling can result in severe visual impairment. Furthermore, the exploration of PDE6D’s interactions with small molecules may lead to novel therapeutic strategies. Overall, the investigation of PDE6D through recombinant protein studies is crucial for elucidating its functions in health and disease, thereby contributing to the development of targeted treatments for retinal disorders and related conditions.
