Cat: PA2000-789DB

Recombinant Human COL6 Protein,His

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Analytical Data

  • Gene name

    COL6

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    COL6;Collagen alpha-1(XIX) chain

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q8LG76

  • Expression Region

    1-406aa

  • AA Sequence

    MMKSLASAVG GKTARACDSC VKRRARWYCA ADDAFLCHAC DGSVHSANPL ARRHERVRLK SASAGKYRHA SPPHQATWHQ GFTRKARTPR GGKKSHTMVF HDLVPEMSTE DQAESYEVEE QLIFEVPVMN SMVEEQCFNQ SLEKQNEFPM MPLSFKSSDE EDDDNAESCL NGLFPTDMEL AQFTADVETL LGGGDREFHS IEELGLGEML KIEKEEVEEE GVVTREVHDQ DEGDETSPFE ISFDYEYTHK TTFDEGEEDE KEDVMKNVME MGVNEMSGGI KEEKKEKALM LRLDYESVIS TWGGQGIPWT ARVPSEIDLD MVCFPTHTMG ESGAEAHHHN HFRGLGLHLG DAGDGGREAR VSRYREKRRT RLFSKKIRYE VRKLNAEKRP RMKGRFVKRS SIGVAH

  • Molecular Weight

    46 kDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

Collagen type VI (COL6) is a crucial extracellular matrix protein that plays significant roles in tissue structure, stability, and cellular interactions. It is primarily found in connective tissues and is known for its role in maintaining tissue integrity and facilitating cell adhesion and migration. Mutations in the genes encoding COL6 can lead to various dystrophic conditions, such as Bethlem myopathy and Ullrich congenital muscular dystrophy. Research into COL6 has gained momentum due to its involvement in muscle diseases and potential implications for regenerative medicine. Scientists are exploring recombinant COL6 proteins for therapeutic purposes, aiming to understand their functional properties and interactions at the molecular level. Furthermore, these studies are crucial for developing treatment strategies that may alleviate muscle degeneration and other related disorders. Recombinant COL6 proteins provide a valuable tool for elucidating the mechanisms of COL6-related diseases and potentially offer therapeutic avenues for restoring tissue function. Understanding COL6’s structure and function is vital for advancing tissue engineering applications and developing novel biomarkers for diagnosing collagen-related pathologies.

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