Analytical Data
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Gene name
PHB2
- Application
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Alternative Names
PHB2;BAP;REA;Prohibitin-2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q99623
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Expression Region
1-299aa
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AA Sequence
MGSSHHHHHHSSGLVPRGSHMGSMAQNLKDLAGRLPAGPRGMGTALKLLL GAGAVAYGVRESVFTVEGGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQY PIIYDIRARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSMYQRLGLD YEERVLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTERAKDFSL ILDDVAITELSFSREYTAAVEAKQVAQQEAQRAQFLVEKAKQEQRQKIVQ AEGEAEAAKMLGEALSKNPGYIKLRKIRAAQNISKTIATSQNRIYLTADN LVLNLQDESFTRGSDSLIKGKK
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Molecular Weight
36 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PHB2 (Prohibitin 2) is a well-characterized member of the prohibitin family of proteins, which are known to play crucial roles in cellular processes such as proliferation, apoptosis, and mitochondrial function. The interest in PHB2 has surged in recent years due to its involvement in various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. Structurally, PHB2 is found in both the mitochondria and the nucleus, where it interacts with various signaling pathways and transcription factors, influencing cell survival and growth. Research has shown that PHB2 can regulate the expression of genes related to energy metabolism and oxidative stress responses, highlighting its potential as a therapeutic target. Additionally, the ability to produce recombinant PHB2 proteins has facilitated the study of its functional mechanisms, interactions, and role in disease pathogenesis. These recombinant proteins are crucial for investigating PHB2's structure-function relationship and developing strategies to modulate its activity for therapeutic applications. Overall, understanding the biological significance of PHB2 through recombinant protein research is vital for elucidating its role in health and disease, potentially leading to novel interventions for related disorders.
