Analytical Data
-
基因名
METTL8
- Application
-
别名
METTL8mRNA N(3)-methylcytidine methyltransferase METTL8; EC 2.1.1.-; Methyltransferase-like protein 8
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q9H825
-
表达区间
1-291 aa
-
氨基酸序列
MNMIWRNSIS CLRLGKVPHR YQSGYHPVAP LGSRILTDPA KVFEHNMWDH MQWSKEEEAA ARKKVKENSA VRVLLEEQVK YEREASKYWD TFYKIHKNKF FKDRNWLLRE FPEILPVDQK PEEKARESSW DHVKTSATNR FSRMHCPTVP DEKNHYEKSS GSSEGQSKTE SDFSNLDSEK HKKGPMETGL FPGSNATFRI LEVGCGAGNS VFPILNTLEN SPESFLYCCD FASGAVELVK SHSSYRATQC FAFVHDVCDD GLPYPFPDGI LDVILLVFVL SSIHPDRTLF I
-
分子量
33.3 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
METTL8, a member of the RNA methyltransferase family, has garnered attention in recent years due to its potential role in regulating gene expression and cellular processes through RNA modifications. As a methyltransferase that specifically targets adenosine residues in RNA, METTL8 may influence various physiological and pathological outcomes, including cell differentiation, proliferation, and stress responses. Given the growing evidence linking RNA methylation to critical biological functions and disease mechanisms, researchers are keen to elucidate the exact biochemical pathways and molecular interactions involving METTL8. Initial studies suggest its involvement in cancer progression and immune responses, highlighting the need for further investigation into its enzymatic activity, substrate specificity, and potential as a therapeutic target. Understanding the functional implications of METTL8 and its reactivity in different cellular contexts could provide insights into RNA metabolism and lead to novel strategies for modulating gene expression in diseases where RNA methylation plays a crucial role. Thus, the study of METTL8 contains significant promise for advancing our knowledge of RNA biology and therapeutic developments in oncology and beyond.
