Analytical Data
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基因名
tetX3
- Application
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别名
tetX3；Flavin-dependent monooxygenase
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q7X2A0
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表达区间
1-378aa
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氨基酸序列
MTLLKYKKITIIGAGPVGLTMARLLQQNGVDITVYERDKDQDARIFGGTLDLHRDSGQEAMKRAGLLQTYYDLALPMGVNIVDEKGNILTTKNVRPENRFDNPEINRNDLRTILLNSLQNDTVIWDRKLVTLEPDKEKWILTFGDKSSETADLVIIANGGMSKVRKFVTDTEVEETGTFNIQADIHQPEVNCPGFFQLCNGNRLMAAHQGNLLFANPNNNGALHFGISFKTPDEWKSKTQVDFQDRNSVVDFLLKKFSDWDERYKELIRLTSSFVGLATRIFPLDKSWKSKRPLPITMIGDAAHLMPPFAGQGVNSGLMDALILSDNLTNGKFNSIEEAIENYEQQMFAYGREAQTESIINETEMFSLDFSFQKLMNL
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分子量
46.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TetX3, a member of the tetracycline-resistance protein family, has garnered significant attention due to its pivotal role in antibiotic resistance. This protein, identified in various pathogenic bacteria, exhibits a unique ability to confer resistance against tetracycline antibiotics by enzymatically modifying their structure. The emergence of TetX3 is particularly concerning in the context of rising antibiotic resistance, which poses a serious threat to global health. Research into TetX3 not only aids in understanding the mechanisms behind antibiotic resistance but also highlights the genetic elements that facilitate its transmission among bacterial populations. Through the study of TetX3, scientists aim to uncover potential targets for novel antibiotic development and strategies to combat resistance. Investigating its structure-function relationship has revealed critical insights into the protein's enzymatic activity, influencing the design of inhibitors that can restore the efficacy of tetracyclines. Moreover, understanding the prevalence and distribution of TetX3 in clinical isolates provides valuable information for epidemiological studies, emphasizing the need for ongoing surveillance and innovative approaches to address the challenge of antimicrobial resistance. This research is crucial as it paves the way for new therapeutic options and informs public health policies aimed at mitigating the impact of resistant infections.
