Analytical Data
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基因名
ABCG8
- Application
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别名
ABCG8；ATP-binding cassette sub-family G member 8
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H221
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表达区间
1-673aa
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氨基酸序列
MAGKAAEERGLPKGATPQDTSGLQDRLFSSESDNSLYFTYSGQPNTLEVRDLNYQVDLASQVPWFEQLAQFKMPWTSPSCQNSCELGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTSIDRRSREQELATREKAQSLAALFLEKVRDLDDFLWKAETKDLDEDTCVESSVTPLDTNCLPSPTKMPGAVQQFTTLIRRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDTAALLFMIGALIPFNVILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGELPEHCAYIIIYGMPTYWLANLRPGLQPFLLHFLLVWLVVFCCRIMALAAAALLPTFHMASFFSNALYNSFYLAGGFMINLSSLWTVPAWISKVSFLRWCFEGLMKIQFSRRTYKMPLGNLTIAVSGDKILSVMELDSYPLYAIYLIVIGLSGGFMVLYYVSLRFIKQKPSQDW
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分子量
75.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ABCG8 is a member of the ATP-binding cassette (ABC) transporters family, which plays a crucial role in lipid metabolism and cholesterol homeostasis. It is primarily expressed in the intestines and liver, where it contributes to the regulation of dietary sterol absorption and secretion. Mutations and polymorphisms in the ABCG8 gene have been linked to various metabolic disorders, including hypercholesterolemia and atherosclerosis. Research has shown that ABCG8 heterodimers with ABCG5 are essential for effective transport of cholesterol and phytosterols, impacting overall cholesterol levels in the blood. The study of recombinant ABCG8 protein facilitates a better understanding of its functional mechanisms, transport activity, and interaction with other proteins. Utilizing recombinant techniques, researchers can investigate how ABCG8 influences lipid absorption and metabolism, which is vital for developing potential therapeutic strategies for metabolic diseases and cardiovascular health. The exploration of ABCG8 not only helps in deciphering the biological implications of ABC transporters but also aids in identifying biomarkers and drug targets for disorders related to lipid imbalance. Therefore, the study of recombinant ABCG8 protein is significant for advancing the field of metabolic research and providing insights into cardiovascular disease prevention and treatment.
