Analytical Data
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基因名
ACACb
- Application
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别名
ACACb；ACC2；ACCB；Acetyl-CoA carboxylase 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O00763
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表达区间
全长
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氨基酸序列
full
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分子量
276.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ACACb (acetyl-CoA carboxylase beta) is a critical enzyme that plays a significant role in fatty acid metabolism and energy homeostasis. It catalyzes the conversion of acetyl-CoA to malonyl-CoA, a key step in fatty acid biosynthesis and regulation of mitochondrial fatty acid oxidation. Dysregulation of ACACb is linked to various metabolic disorders, including obesity, insulin resistance, and cardiovascular diseases. Given its central role in metabolic pathways, ACACb is an attractive target for therapeutic interventions aimed at treating these conditions. Recent advances in molecular biology and protein engineering have enabled the production of recombinant ACACb, facilitating detailed studies of its structure, function, and regulatory mechanisms. Researchers have focused on understanding the enzyme's allosteric regulation and post-translational modifications, which influence its activity and stability. Moreover, recombinant ACACb serves as a valuable tool for drug discovery, allowing for high-throughput screening of potential inhibitors that could modulate its activity. This research not only enhances our understanding of metabolic regulation but also paves the way for novel therapeutic strategies to combat metabolic diseases linked to ACACb dysfunction.
