Analytical Data
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基因名
POLR2E
- Application
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别名
URI1;C19orf2;NNX3;PPP1R19;Unconventional prefoldin RPB5 interactor 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P19388
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表达区间
1-210aa
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氨基酸序列
MDDEEETYRL WKIRKTIMQL CHDRGYLVTQ DELDQTLEEF KAQSGDKPSE GRPRRTDLTV LVAHNDDPTD QMFVFFPEEP KVGIKTIKVY CQRMQEENIT RALIVVQQGM TPSAKQSLVD MAPKYILEQF LQQELLINIT EHELVPEHVV MTKEEVTELL ARYKLRENQL PRIQAGDPVA RYFGIKRGQV VKIIRPSETA GRYITYRLVQ
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
POLR2E, a subunit of RNA polymerase II, plays a crucial role in the transcription of protein-coding genes, which are essential for cell function and regulation. The study of POLR2E recombinant proteins has gained attention due to their implications in understanding the fundamental mechanisms of gene expression and their potential link to various diseases, including cancer. The POLR2E subunit is involved in the formation of the core enzyme responsible for synthesizing mRNA, and its proper function is vital for accurate transcription. Abnormalities or mutations in POLR2E can lead to defective transcription machinery, resulting in altered gene expression patterns that are associated with cellular dysfunction and oncogenesis. Researchers are focused on producing recombinant POLR2E proteins to investigate their structure, function, and interactions with other transcription factors and regulatory elements. This research not only enhances our understanding of the transcriptional process but also supports the development of targeted therapeutic strategies aimed at rectifying transcriptional dysregulation seen in various diseases. By elucidating the role of POLR2E in transcriptional regulation, scientists hope to discover novel insights into cellular biology and the underlying mechanisms of disease progression.
