Analytical Data
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基因名
POMC
- Application
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别名
POMC;Pro-opiomelanocortin
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P01189
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表达区间
27-267aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMWCLESSQCQDLTTESNLLECIRACKPDLS AETPMFPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKRE DVSAGEDCGPLPEGGPEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRR PVKVYPNGAEDESAEAFPLEFKRELTGQRLREGDGPDGPADDGAGAQADL EHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFK NAIIKNAYKKGE
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分子量
29 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Pro-opiomelanocortin (POMC) is a precursor polypeptide with significant roles in various physiological processes, including appetite regulation, stress response, and pigmentation. POMC is primarily expressed in the pituitary gland and is cleaved into several biologically active peptides, such as adrenocorticotropic hormone (ACTH) and melanocyte-stimulating hormones (MSHs). Research into POMC recombinant proteins has gained traction due to their potential therapeutic implications in treating obesity, metabolic disorders, and adrenal insufficiencies. Given POMC's crucial role in energy homeostasis, alterations in its signaling pathways are linked to obesity and other metabolic diseases. Recombinant POMC proteins can be utilized in studies to understand the mechanisms of action at the molecular level, as well as to develop novel strategies for targeted drug delivery and therapeutic interventions. Furthermore, advances in genetic engineering techniques have allowed for the creation of modified POMC variants, enhancing the specificity and efficacy of peptide-based therapies. Overall, the investigation of POMC recombinant proteins contributes to a deeper understanding of their biological functions and holds promise for clinical applications in managing metabolic disorders and related conditions.
