Analytical Data
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基因名
PPA1
- Application
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别名
PPA1;IOPPP;PP;Inorganic pyrophosphatase
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15181
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表达区间
1-289aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSHMSGFSTEERAAPFSLEYRVFLKNEKG QYISPFHDIPIYADKDVFHMVVEVPRWSNAKMEIATKDPLNPIKQDVKKG KLRYVANLFPYKGYIWNYGAIPQTWEDPGHNDKHTGCCGDNDPIDVCEIG SKVCARGEIIGVKVLGILAMIDEGETDWKVIAINVDDPDAANYNDINDVK RLKPGYLEATVDWFRRYKVPDGKPENEFAFNAEFKDKDFAIDIIKSTHDH WKALVTKKTNGKGISCMNTTLSESPFKCDPDAARAIVDALPPPCESACTV PTDVDKWFHHQKN
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分子量
35 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PPA1, or inorganic pyrophosphatase 1, is a crucial enzyme that plays a significant role in cellular energy metabolism and pyrophosphate hydrolysis, which is vital for various biological processes, including nucleic acid synthesis and ATP regeneration. Its activity influences key metabolic pathways, making it a potential target for studying diseases related to energy metabolism, such as cancer and metabolic disorders. Despite its importance, the structural and functional characteristics of PPA1 remain under-explored, especially in relation to its role in pathogen interactions and potential implications in therapeutic strategies. Recent advances in recombinant protein technologies have enabled the production of PPA1 in different host systems, allowing for detailed studies of its biochemical properties and interactions with other molecules. Understanding the properties of recombinant PPA1 can lead to insights into its mechanism of action, regulation, and potential as a drug target. Furthermore, the development of PPA1 inhibitors may offer new avenues for treating diseases linked to pyrophosphate dysregulation. Thus, ongoing research into PPA1 and its recombinant variants is vital for elucidating its biological functions and exploring its therapeutic potential.
