Analytical Data
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Gene name
MOBKL2C
- Application
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Alternative Names
MOB3C; MOBKL2C; MOB kinase activator 3C; Mob1 homolog 2C; Mps one binder kinase activator-like 2C
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q70IA8
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Expression Region
1-216 aa
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AA Sequence
MALCLKQVFA KDKTFRPRKR FEPGTQRFEL YKKAQASLKS GLDLRSVVRL PPGENIDDWI AVHVVDFFNR INLIYGTMAE RCSETSCPVM AGGPRYEYRW QDERQYRRPA KLSAPRYMAL LMDWIEGLIN DEEVFPTRVG VPFPKNFQQV CTKILTRLFR VFVHVYIHHF DSILSMGAEA HVNTCYKHFY YFIREFSLVD QRELEPLREM TERICH
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Molecular Weight
25.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MOBKL2C, or MOB kinase activator 2C, is a crucial protein that plays a significant role in cell signaling pathways, particularly in regulating the Hippo pathway, which is vital for controlling cell growth, proliferation, and apoptosis. Dysregulation of the Hippo pathway is linked to various cancers and developmental disorders, making MOBKL2C a potential target for therapeutic interventions. Recent studies have highlighted the importance of recombinantly expressing MOBKL2C to elucidate its structure and function, enabling researchers to investigate its interactions with other signaling molecules and understand its biological roles in cellular processes. The production of recombinant MOBKL2C allows for in-depth biochemical studies, including protein-protein interaction assays, crystal structure determination, and functional assays in cellular models. These investigations are crucial for identifying how MOBKL2C modulates signaling pathways and contributes to tumorigenesis or other diseases. Furthermore, understanding the molecular mechanisms behind MOBKL2C can lead to the development of novel strategies for cancer treatment and regenerative medicine, highlighting the importance of this protein in biological research and potential therapeutic applications. Overall, the study of recombinant MOBKL2C is an essential step toward uncovering its multifaceted roles in health and disease.
