Analytical Data
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基因名
PPM1G
- Application
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别名
PPM1G;PPM1C;Protein phosphatase 1G
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O15355
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表达区间
2-546aa
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氨基酸序列
GAYLSQPNT VKCSGDGVGA PRLPLPYGFS AMQGWRVSME DAHNCIPELD SETAMFSVYD GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALEDAFLA IDAKLTTEEV IKELAQIAGR PTEDEDEKEK VADEDDVDNE EAALLHEEAT MTIEELLTRY GQNCHKGPPH SKSGGGTGEE PGSQGLNGEA GPEDSTRETP SQENGPTAKA YTGFSSNSER GTEAGQVGEP GIPTGEAGPS CSSASDKLPR VAKSKFFEDS EDESDEAEEE EEDSEECSEE EDGYSSEEAE NEEDEDDTEE AEEDDEEEEE EMMVPGMEGK EEPGSDSGTT AVVALIRGKQ LIVANAGDSR CVVSEAGKAL DMSYDHKPED EVELARIKNA GGKVTMDGRV NGGLNLSRAI GDHFYKRNKN LPPEEQMISA LPDIKVLTLT DDHEFMVIAC DGIWNVMSSQ EVVDFIQSKI SQRDENGELR LLSSIVEELL DQCLAPDTSG DGTGCDNMTC IIICFKPRNT AELQPESGKR KLEEVLSTEG AEENGNSDKK KKAKRD
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PPM1G, or Protein Phosphatase Magnesium/Manganese-dependent 1G, is a serine/threonine phosphatase that plays a crucial role in cellular signaling pathways by dephosphorylating various substrates, thereby regulating diverse biological processes such as cell cycle progression, apoptosis, and stress response. Research into PPM1G has gained prominence due to its potential implications in cancer biology, where aberrant phosphorylation patterns often lead to oncogenesis. Elevated levels of PPM1G have been correlated with tumor progression in several cancer types, suggesting its involvement in cellular proliferation and survival mechanisms. Additionally, PPM1G is implicated in the regulation of immune responses and inflammation, making it a target of interest in autoimmune diseases. The study of recombinant PPM1G protein has facilitated a deeper understanding of its enzymatic properties and substrate interactions, paving the way for the development of potential therapeutic strategies. By comparing the effects of PPM1G under different physiological and pathological conditions, researchers aim to uncover the precise mechanisms by which this phosphatase influences various signaling pathways. The elucidation of PPM1G's functions not only enhances our understanding of cellular homeostasis but also highlights its potential as a biomarker for disease progression and a target for innovative treatment options.
