Analytical Data
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基因名
IGF-I/IGF-1
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简介
IGF-I/IGF-1 Protein is an insulin-like growth factor that possesses both growth-promoting and metabolic-regulating functions. IGF-I/IGF-1 Protein is also a neurotrophic factor with neuroprotective and neuroplasticity-regulating activities. IGF-I/IGF-1 Protein plays a key role in growth and development, cell proliferation, metabolic regulation and other aspects. IGF-I/IGF-1 Protein, Mouse is a recombinant IGF-I/IGF-1 protein expressed by E. coli without a tag[1][2].
- Application
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生物活性
1.The ED50 is <10>1 × 105 units/mg. 2.Measured in a serum-free cell proliferation assay using MCF-7 human breast cancer cells. The ED50 for this effect is <9>1.03×105 units/mg. Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. The ED50 for this effect is 9.164 ng/mL. corresponding to a specific activity is 1.03×105 units/mg.
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别名
rMuIGF-1; IGF-IA; Somatamedin C; MGF; IGF-I
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种属
Mouse
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 95% as determined by reducing SDS-PAGE.
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蛋白编号
P05017-1
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表达区间
G49-A118
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蛋白长度
Full Length of Isoform-1 Mature Protein
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分子量
8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Insulin-like Growth Factor I (IGF-I), also known as IGF-1, is a crucial peptide hormone that plays a significant role in growth, development, and metabolic regulation. It is primarily produced in the liver in response to growth hormone (GH) stimulation and is involved in cellular growth, differentiation, and survival. Research into IGF-I/IGF-1 recombinant proteins has garnered attention due to their potential therapeutic applications, particularly in conditions characterized by growth deficiencies, such as growth hormone insensitivity, Turner syndrome, and idiopathic short stature. Additionally, IGF-I has been implicated in various metabolic disorders, including obesity and diabetes. The ability to produce recombinant IGF-1 in a laboratory setting allows for the exploration of its biological effects, mechanisms of action, and potential uses in regenerative medicine and muscle-wasting diseases. Furthermore, ongoing studies investigate the role of IGF-I in aging and how it affects tissue repair and muscle regeneration. Despite its therapeutic promise, concerns exist regarding the appropriate usage and potential side effects of IGF-I therapies. As research continues to unveil the complexities of IGF-I signaling pathways and their interactions with other hormonal systems, the development of IGF-I recombinant proteins presents a valuable opportunity to create targeted treatments that can enhance growth and overall metabolic health.
