Analytical Data
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Gene name
DES1-3 IGF-I/IGF-1
- Application
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Biological Activity
Measured in cell proliferation assay using MCF-7 human breast cancer cells. The ED50 for this effect is ≤65 ng/mL. Measured in a serum-free cell proliferation assay using MCF-7 human breast cancer cells. The ED50 for this effect is 1.392 ng/mL. corresponding to a specific activity is 7.189×105 units/mg.
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Alternative Names
rHuIGF-1; IGF-IA; Somatamedin C; MGF; IGF-I
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Species
Human
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 95% as determined by reducing SDS-PAGE.
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Uniprot
P05019-1
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Expression Region
T52-A118
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Protein Length
Full Length of Isoform-1 Mature Protein
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Molecular Weight
9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DES1-3 IGF-I/IGF-1 recombinant proteins are an important area of research due to their significant role in growth and development in mammals. Insulin-like Growth Factor I (IGF-I) is a key mediator of growth hormone action and is crucial for cellular proliferation and differentiation. The recombinant form of IGF-I, specifically DES1-3 IGF-I, has been engineered to enhance its biological potency and specificity. This modified variant exhibits improved affinity for IGF receptors, leading to more pronounced physiological effects. Research has shown that DES1-3 IGF-I plays a critical role in various biological processes, including muscle growth, bone density enhancement, and metabolic regulation. Moreover, the therapeutic potential of IGF-I recombinant proteins extends to treating growth disorders, degenerative diseases, and even age-related conditions. The unique properties of DES1-3 IGF-I render it a promising candidate for various clinical applications, prompting ongoing studies to elucidate its mechanisms of action, optimize its therapeutic efficacy, and evaluate its safety profile. Understanding the implications of this recombinant protein could pave the way for novel therapeutic strategies to enhance health outcomes across different age groups.
