Analytical Data
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基因名
RAB5B
- Application
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别名
RAB5B;Ras-related Protein Rab-5B
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P61020
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表达区间
1-215aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSMTSRSTARPNGQPQASKICQFKLVLLG ESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQSVCLDDTTVKFEIWDTA GQERYHSLAPMYYRGAQAAIVVYDITNQETFARAKTWVKELQRQASPSIV IALAGNKADLANKRMVEYEEAQAYADDNSLLFMETSAKTAMNVNDLFLAI AKKLPKSEPQNLGGAAGRSRGVDLHEQSQQNKSQCCSN
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分子量
26 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RAB5B is a member of the RAB family of small GTPases that plays a critical role in the regulation of endocytic pathways, actin cytoskeleton dynamics, and signal transduction processes. It primarily functions in the early stages of endocytosis, where it facilitates the fusion of early endosomes and contributes to the maturation of these organelles. Understanding the structure and function of RAB5B is essential in elucidating its involvement in various cellular processes, including nutrient uptake, receptor recycling, and pathogen entry. Recently, research has indicated that dysregulation of RAB5B is associated with several diseases, including cancer and neurodegenerative disorders, highlighting its potential as a therapeutic target. The production of RAB5B recombinant protein allows for in-depth studies of its biochemical properties, interaction partners, and role in cellular signaling pathways. Further characterization of RAB5B through recombinant techniques can provide valuable insights into its functional mechanisms and implications in health and disease, paving the way for developing novel therapeutic strategies.
