Analytical Data
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Gene name
SCO1
- Application
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Alternative Names
SCO1;SCOD1;Protein SCO1 homolog. mitochondrial
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75880
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Expression Region
132-301aa
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AA Sequence
MGKPLLGGPF SLTTHTGERK TDKDYLGQWL LIYFGFTHCP DVCPEELEKM IQVVDEIDSI TTLPDLTPLF ISIDPERDTK EAIANYVKEF SPKLVGLTGT REEVDQVARA YRVYYSPGPK DEDEDYIVDH TIIMYLIGPD GEFLDYFGQN KRKGEIAASI ATHMRPYRKK SLEHHHHHH
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Molecular Weight
21 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SCO1 (Synthesis of cytochrome c oxidase 1) is a crucial protein involved in the metalation and assembly of cytochrome c oxidase, a key component of the mitochondrial respiratory chain. The importance of SCO1 is underscored by its role in cellular energy production and the potential consequences of its dysfunction, which can lead to various mitochondrial diseases and disorders linked to impaired oxidative phosphorylation. Research has increasingly focused on understanding the structural and functional properties of SCO1, as well as its interactions with other assembly factors and metal ions, particularly copper. Recombinant SCO1 protein has been produced to facilitate detailed studies on its enzymatic mechanisms and its role in copper delivery, thereby enhancing our understanding of mitochondrial biology. Investigating SCO1 at the molecular level can provide insights into the pathophysiology of metalloenzyme-related diseases, contributing to the development of therapeutic strategies targeting mitochondrial dysfunction. As such, SCO1 represents a significant subject of interest within the fields of biochemistry and molecular biology, with ongoing research aimed at elucidating its precise functions and regulatory mechanisms within cells. This knowledge is critical for uncovering the broader implications of SCO1 in health and disease, particularly in the context of inherited mitochondrial pathologies.
