Analytical Data
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Gene name
MC3R
- Application
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Alternative Names
MC3R；Melanocortin receptor 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P41968
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Expression Region
1-360aa
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AA Sequence
MSIQKTYLEGDFVFPVSSSSFLRTLLEPQLGSALLTAMNASCCLPSVQPT LPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVILAV VRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFI QHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALT LIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLF ARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLV LIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREI LCGCNGMNLG
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Molecular Weight
67 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The melanocortin-3 receptor (MC3R) is a G protein-coupled receptor that plays a crucial role in energy homeostasis, body weight regulation, and influencing food intake. Studies have identified that variations or mutations in the MC3R gene are associated with obesity and metabolic disorders, highlighting its importance in understanding obesity-related pathophysiology. MC3R is predominantly expressed in the central nervous system, particularly in regions of the hypothalamus responsible for appetite regulation. Its ligands, primarily melanocyte-stimulating hormones, activate downstream signaling pathways that modulate appetite and energy expenditure. Research has focused on exploring the receptor's structure, function, and pharmacological properties to better comprehend its role in these critical physiological processes. Recombining the MC3R protein has allowed scientists to study its interactions with various ligands and the consequent signaling mechanisms in controlled settings, paving the way for potential therapeutic interventions in obesity and related metabolic disorders. Understanding MC3R's mechanisms can lead to novel strategies for treating conditions linked to energy imbalance, making it a promising target in the field of metabolic research.
