Analytical Data
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Gene name
ADAD1
- Application
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Alternative Names
ADAD1; TENR; Adenosine deaminase domain-containing Protein 1; Testis nuclear RNA-binding Protein
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96M93
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Expression Region
1-565aa
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AA Sequence
MASNNHWFQSSQVPSFAQMLKKNLPVQPATKTITTPTGWSSESYGLSKMASKVTQVTGNFPEPLLSKNLSSISNPVLPPKKIPKEFIMKYKRGEINPVSALHQFAQMQRVQLDLKETVTTGNVMGPYFAFCAVVDGIQYKTGLGQNKKESRSNAAKLALDELLQLDEPEPRILETSGPPPFPAEPVVLSELAYVSKVHYEGRHIQYAKISQIVKERFNQLISNRSEYLKYSSSLAAFIIERAGQHEVVAIGTGEYNYSQDIKPDGRVLHDTHAVVTARRSLLSKNPAMMEKSIFCTEPTSNLLTLKQNINICLYMNQLPKGSAQIKSQLRLNPHSISAFEANEELCLHVAVEGKIYLTVYCPKDGVNRISSMSSSDKLTRWEVLGVQGALLSHFIQPVYISSILIGDGNCSDTRGLEIAIKQRVDDALTSKLPMFYLVNRPHISLVPSAYPLQMNLEYKFLSLNWAQGDVSLEIVDGLSGKITESSPFKSGMSMASRLCKAAMLSRFNLLAKEAKKELLEAGTYHAAKCMSASYQEAKCKLKSYLQQHGYGSWIVKSPCIEQFNM
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Molecular Weight
89.2 KDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ADAD1, or adenosine deaminase acting on RNA 1, is a key RNA-binding protein involved in post-transcriptional gene regulation. Research into ADAD1 has gained momentum due to its potential implications in various biological processes and diseases, including cancer and neurodegenerative disorders. The protein is known to play critical roles in RNA editing and splicing, influencing the stability and translation of target mRNAs. Dysregulation of ADAD1 expression and function has been linked to altered cellular responses, contributing to tumorigenesis and other pathological conditions. Consequently, the study of ADAD1 recombination proteins has emerged as a promising avenue for understanding its precise molecular mechanisms and therapeutic potential. Researchers are exploring the engineering of ADAD1 to enhance its stability, specificity, and efficacy in a range of applications, from basic research to therapeutic interventions. By elucidating the roles of ADAD1 and its recombinant variants, scientists aim to develop strategies for targeted therapies that could address the underlying molecular dysregulation in various diseases, paving the way for innovative treatments and improved patient outcomes.
