Analytical Data
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Gene name
STMN3
- Application
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Alternative Names
STMN3；SCLIP；Stathmin-3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NZ72
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Expression Region
39-180aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MDMEVKQLDK RASGQSFEVI LKSPSDLSPE SPMLSSPPKK KDTSLEELQK RLEAAEERRK TQEAQVLKQL AERREHEREV LHKALEENNN FSRQAEEKLN YKMELSKEIR EAHLAALRER LREKELHAAE VRRNKEQREE MSG
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Molecular Weight
19 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
STMN3 (Stathmin-like protein 3) is a member of the stathmin family of proteins, which play crucial roles in the regulation of microtubule dynamics and cellular processes such as cell signaling, proliferation, and differentiation. Research into STMN3 has garnered significant attention due to its potential involvement in various neurological disorders and cancers. Unlike its well-studied counterpart, stathmin (STMN1), which is known for its role in destabilizing microtubules, STMN3's specific functions and mechanisms remain less defined. Recent studies suggest that STMN3 could be implicated in neurodegenerative diseases, particularly Alzheimer’s disease, where microtubule instability is a hallmark. Moreover, its expression patterns in different tissues and cell types indicate that it may have distinct roles in cellular contexts. Recombination techniques to produce STMN3 as a recombinant protein allow researchers to study its biochemical properties and interactions with other cellular components in vitro. Understanding STMN3's structure and function is essential for unveiling its contributions to disease mechanisms and could lead to the identification of novel therapeutic targets. Thus, investigating STMN3 not only enhances our fundamental knowledge of cellular biology but also holds promise for advancing approaches to treat conditions associated with its dysregulation.
