Analytical Data
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Gene name
VRK2
- Application
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Alternative Names
VRK2；Serine/threonine-Protein kinase VRK2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86Y07
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Expression Region
1-508aa
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AA Sequence
MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLSEETNADVYYYRIIIPVLLMLVFLALFFL
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Molecular Weight
58.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
VRK2 (Vaccinia-related kinase 2) is a serine/threonine kinase belonging to the VRK family, which plays a crucial role in various cellular processes, including cell proliferation, apoptosis, and DNA damage response. Its dysregulation has been associated with several diseases, including cancer, where it is implicated in tumor progression and metastasis. Research has shown that VRK2 can modulate key signaling pathways and influence the activity of transcription factors, such as p53, thus impacting cell cycle regulation. The understanding of VRK2's structure and function is pivotal for elucidating its role in cellular mechanisms and disease pathogenesis. Recent studies have focused on the development of VRK2 recombinant proteins to explore its biochemical properties, interactions, and potential as a therapeutic target. By investigating the enzymatic activity and substrate specificity of VRK2, researchers aim to uncover novel insights into its functional dynamics and the broader implications for therapeutic interventions in related pathologies. The study of VRK2 not only enhances our understanding of kinase biology but also opens avenues for targeted therapies, providing a foundation for future clinical research in cancer and other diseases linked to VRK2 dysregulation.
