Analytical Data
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Gene name
CBLN3
- Application
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Alternative Names
CBLN3；Cerebellin-3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6UW01
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Expression Region
33-205aa
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AA Sequence
QEGSEPVL LEGECLVVCE PGRAAAGGPG GAALGEAPPG RVAFAAVRSH HHEPAGETGN GTSGAIYFDQ VLVNEGGGFD RASGSFVAPV RGVYSFRFHV VKVYNRQTVQ VSLMLNTWPV ISAFANDPDV TREAATSSVL LPLDPGDRVS LRLRRGNLLG GWKYSSFSGF LIFPL
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Molecular Weight
21.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CBLN3, or Cbln-3, is a member of the C1q/TNF-related protein family, which has garnered attention due to its potential roles in synaptic function and neurodevelopment. Research suggests that CBLN3 is involved in the modulation of synaptic plasticity and may play a key role in neuronal communication and stabilization of synapses. Its expression patterns are often studied in the context of neurological disorders, as altered levels of CBLN3 may contribute to cognitive dysfunctions and psychiatric conditions. Understanding the biochemical properties and functional implications of CBLN3 is crucial for elucidating its role in synaptic integrity and neuronal network formation. The recombinant protein of CBLN3 is used in various experimental approaches to investigate its interactions with receptors and other synaptic proteins, enhancing the understanding of how it influences synaptic connectivity. Additionally, insights into CBLN3's mechanisms may pave the way for novel therapeutic strategies aimed at treating neurodevelopmental and neurodegenerative diseases, making it a significant focus in neuroscience research. Studies of CBLN3's structure-function relationship are essential for developing drugs that target synaptic dysfunctions associated with various neurological disorders, underscoring its importance in both basic and applied biomedical research.
