Analytical Data
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Gene name
ALS2CR7
- Application
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Alternative Names
CDK15; ALS2CR7; PFTK2Cyclin-dependent kinase 15; EC 2.7.11.22
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96Q40
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Expression Region
1-349aa
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AA Sequence
MTSFHPRGLQAARAQKFKSKRPRSNSDCFQEEDLRQGFQWRKSLPFGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDE
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Molecular Weight
66 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ALS2CR7 is a gene located on human chromosome 7 that encodes a protein involved in multiple cellular processes, including endosomal trafficking and neuronal function. Research into ALS2CR7 has gained momentum due to its association with various neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS) and certain types of hereditary spastic paraplegia. Understanding the structure and function of ALS2CR7 and its protein product is crucial for elucidating the molecular mechanisms underlying these disorders. Experimental approaches, including the production of recombinant ALS2CR7 protein, have been employed to investigate its biochemical properties and functional roles in cell signaling and protein interactions. Insights gained from these studies could pave the way for novel therapeutic strategies targeting ALS2CR7-related pathways. Furthermore, the exploration of ALS2CR7’s role in neurodegeneration may contribute to a broader understanding of the pathophysiology of ALS and enhance the development of diagnostic tools, potentially benefiting affected individuals and their families.
