Analytical Data
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Gene name
XRCC2
- Application
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Alternative Names
XRCC2；DNA repair Protein XRCC2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O43543
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Expression Region
1-280aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMCSAFHR AESGTELLAR LEGRSSLKEI EPNLFADEDS PVHGDILEFH GPEGTGKTEM LYHLTARCIL PKSEGGLEVE VLFIDTDYHF DMLRLVTILE HRLSQSSEEI IKYCLGRFFL VYCSSSTHLL LTLYSLESMF CSHPSLCLLI LDSLSAFYWI DRVNGGESVN LQESTLRKCS QCLEKLVNDY RLVLFATTQT IMQKASSSSE EPSHASRRLC DVDIDYRPYL CKAWQQLVKH RMFFSKQDDS QSSNQFSLVS RCLKSNSLKK HFFIIGESGV EFC
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Molecular Weight
34 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
XRCC2 is a crucial gene that encodes a protein involved in the DNA repair process, particularly in the context of homologous recombination, a mechanism essential for maintaining genomic stability. It plays an important role in the repair of double-strand breaks, which can result from various factors, including environmental stressors and normal cellular processes. Mutations or deficiencies in XRCC2 have been linked to increased susceptibility to various cancers and genetic disorders, highlighting its significance in the maintenance of DNA integrity. Research has shown that XRCC2 interacts with other repair proteins and is integral to the formation of repair complexes at sites of DNA damage. Given its critical role in DNA repair pathways, XRCC2 has become a focal point in cancer research, with studies aiming to elucidate its function, regulation, and potential as a therapeutic target. The characterization of XRCC2 and its recombinatory protein structure could lead to advancements in gene therapy, targeted treatments, and a deeper understanding of cancer mechanisms. The exploration of XRCC2's role in cell survival following DNA damage emphasizes its importance not only in cancer biology but also in the field of molecular genetics, where understanding the intricate details of DNA repair pathways can inform broader research on genetic resilience and therapeutic interventions.
