Analytical Data
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Gene name
BCL2L13
- Application
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Alternative Names
BCL2L13; MIL1; CD003; Bcl-2-like Protein 13; Bcl2-L-13; Bcl-rambo; Protein Mil1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BXK5
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Expression Region
1-485aa
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AA Sequence
MASSSTVPLGFHYETKYVVLSYLGLLSQEKLQEQHLSSPQGVQLDIASQSLDQEILLKVKTEIEEELKSLDKEISEAFTSTGFDRHTSPVFSPANPESSMEDCLAHLGEKVSQELKEPLHKALQMLLSQPVTYQAFRECTLETTVHASGWNKILVPLVLLRQMLLELTRRGQEPLSALLQFGVTYLEDYSAEYIIQQGGWGTVFSLESEEEEYPGITAEDSNDIYILPSDNSGQVSPPESPTVTTSWQSESLPVSLSASQSWHTESLPVSLGPESWQQIAMDPEEVKSLDSNGAGEKSENNSSNSDIVHVEKEEVPEGMEEAAVASVVLPARELQEALPEAPAPLLPHITATSLLGTRESDTEVITVEKSSPATSLFVELDEEEVKAATTEPTEVEEVVPALEPTETLLSEKEINAREESLVEELSPASEKKPVPPSEGKSRLSPAGEMKPMPLSEGKSILLFGGAAAVAILAVAIGVALALRKK
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Molecular Weight
79.09 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BCL2L13 is a member of the BCL-2 family of proteins, which play crucial roles in regulating apoptosis and cellular survival. Recent studies have uncovered that BCL2L13 possesses a unique function beyond its apoptotic regulatory capabilities, specifically its involvement in mitochondrial dynamics and cellular responses to stress. The gene encoding BCL2L13 has been linked to various cellular processes, including oxidative stress response and inflammation, indicating its potential impact on diseases such as neurodegenerative disorders and cancer. The functional characterization of BCL2L13 is of significant interest to researchers aiming to understand its mechanistic roles in cell survival and death. A key focus has been on the production and investigation of recombinant BCL2L13 proteins, which facilitate the study of its structure-function relationships and interactions with other mitochondrial proteins. Such studies could reveal novel insights into the molecular mechanisms underlying mitochondrial dysfunction and apoptosis, potentially leading to the development of therapeutic strategies targeting BCL2L13-related pathways in disease contexts. The exploration of BCL2L13 as a therapeutic target further emphasizes the relevance of this protein in maintaining mitochondrial integrity and cellular homeostasis, underscoring the importance of ongoing research in this area.
