Analytical Data
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基因名
BMS1
- Application
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别名
BMS1; BMS1L; KIAA0187Ribosome biogenesis Protein BMS1 homolog; Ribosome assembly Protein BMS1 homolog
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q14692
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表达区间
1-403aa
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氨基酸序列
MGKVWKQQMYPQYATYYYPQYLQAKQSLVPAHPMAPPSPSTTSSNNNSSSSSNSGWDQLSKTNLYIRGLPPHTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGFVDFDSPAAAQKAVSALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELENMLKPFGQVISTRILRDSSGTSRGVGFARMESTEKCEAVIGHFNGKFIKTPPGVSAPTEPLLCKFADGGQKKRQNPNKYIPNGRPWHREGEAGMTLTYDPTTAAIQNGFYPSPYSIATNRMITQTSITPYIASPVSAYQVQSPSWMQPQPYILQHPGAVLTPSMEHTMSLQPASMISPLAQQMSHLSLGSTGTYMPATSAMQGAYLPQYAHMQTTAVPVEEASGQQQVAVETSNDHSPYTFQPNK
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分子量
70.07 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BMS1 is a vital protein involved in ribosome biogenesis, particularly in the processing and maturation of ribosomal RNA (rRNA) and the assembly of ribosomal subunits. Research into BMS1 has gained importance due to its role in cellular growth and proliferation, as well as its implications in various diseases, including cancer and ribosomopathies—disorders caused by defects in ribosome production. BMS1 is known to interact with multiple nucleolar proteins, contributing to the dynamic processes of rRNA transcription and ribosome assembly. Its expression is tightly regulated, and alterations can lead to impaired ribosome function, impacting protein synthesis and cellular homeostasis. Understanding the structure and function of BMS1, especially when reconstituted in vitro, could provide insights into its mechanistic role and potential therapeutic targets. Overall, the study of BMS1 recombinant proteins enhances our knowledge of ribosome biology and its intricate networks, offering avenues for biomedical research and potential interventions in related diseases.
