Analytical Data
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Gene name
POF1B
- Application
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Alternative Names
2310066B14Rik; FLJ22792; POF; Pof1b; POF1B_HUMAN; POF2B; Premature ovarian failure protein 1B; Protein POF1B; RGD1560798; RP1-75N13.2; RP23-336F13.1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8WVV4
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Expression Region
1-589 aa
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AA Sequence
MSSSYWSETS SSSCGTQQLP EVLQCQPQHY HCYHQSSQAQ QPPEKNVVYE RVRTYSGPMN KVVQALDPFN SREVLSPLKT TSSYQNLVWS DHSQELHSPT LKISTCAPST LHITQNTEQE LHSPTVKLTT YPQTTIRKYV VQNPEQEPLS QFLRGSHFFP GNNVIYEKTI RKVEKLNTDQ GCHPQAQCHH HIIQQPQVIH SAHWQQPDSS QQIQAITGNN PISTHIGNEL CHSGSSQICE QVIIQDDGPE KLDPRYFGEL LADLSRKNTD LYHCLLEHLQ RIGGSKQDFE STDESEDIES LIPKGLSEFT KQQIRYILQM RGMSDKSLRL VLSTFSNIRE ELGHLQNDMT SLENDKMRLE KDLSFKDTQL KEYEELLASV RANNHQQQQG LQDSSSKCQA LEENNLSLRH TLSDMEYRLK ELEYCKRNLE QENQNLRMQV SETCTGPMLQ AKMDEIGNHY TEMVKNLRME KDREICRLRS QLNQYHKDVS KREGSCSDFQ FKLHELTSLL EEKDSLIKRQ SEELSKLRQE IYSSHNQPST GGRTTITTKK YRTQYPILGL LYDDYEYIPP GSETQTIVIE KTEDKYTCP
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Molecular Weight
68.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
POF1B, or POF1B protein, has garnered significant attention in the field of molecular biology and genetics due to its critical role in cellular processes. Initially identified as a protein involved in cell signaling and regulation, POF1B is particularly relevant in the context of developmental biology and disease. Research has revealed that mutations in the POF1B gene are associated with specific developmental disorders, particularly those affecting the craniofacial region, highlighting its importance in human health. The study of POF1B at the molecular level is crucial for understanding its functional mechanisms and interactions within cellular pathways. Furthermore, the investigation of POF1B as a recombinant protein has great implications for therapeutic applications, especially in gene therapy and regenerative medicine. Through advanced techniques in protein engineering and expression systems, researchers aim to produce POF1B in a laboratory setting, allowing for a deeper exploration of its structure and function. Understanding the role of POF1B not only contributes to our knowledge of genetic disorders but also paves the way for potential interventions and treatments that could ameliorate the effects of mutations associated with this protein. As research progresses, POF1B continues to be a focal point for scientists aiming to unravel the complexities of genetic regulation and its impact on human development.
