Analytical Data
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基因名
CDNF
- Application
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别名
CDNF;ARMETL1;Cerebral dopamine neurotrophic factor
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q49AH0
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表达区间
25-187aa
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氨基酸序列
QGQEAGGRPGADCEVCKEFLNRFYKSLIDRGVNFSLDTIEKELISFCLDT KGKENRLCYYLGATKDAATKILSEVTRPMSVHMPAMKICEKLKKLDSQIC ELKYEKTLDLASVDLRKMRVAELKQILHSWGEECRACAEKTDYVNLIQEL APKYAATHPKTEL
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分子量
19 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDNF (Cerebral Dopamine Neurotrophic Factor) is a relatively novel neurotrophic factor that has garnered significant attention in the field of neuroscience and neurodegenerative diseases research. Originally identified for its protective effects on dopaminergic neurons, CDNF has been shown to play a crucial role in promoting neuronal survival, supporting neuronal function, and facilitating the repair of damaged neural tissues. Its unique ability to cross the blood-brain barrier and its potential therapeutic benefits make it an appealing candidate for treating conditions like Parkinson's disease, Alzheimer's disease, and other neurodegenerative disorders. Research has demonstrated that CDNF can not only enhance the survival of dopaminergic neurons but also restore neurotransmitter balance and improve motor functions in animal models of neurodegenerative diseases. Scientists are exploring the structural and functional characteristics of CDNF, including its interactions with cellular receptors and downstream signaling pathways, to better understand its mechanisms of action. Additionally, the development of recombinant CDNF proteins for clinical applications is an active area of investigation. These studies aim to evaluate the efficacy of CDNF in promoting neuroprotection and neuroregeneration, with the ultimate goal of advancing toward potential therapeutic interventions for patients suffering from debilitating neurological conditions. The ongoing research into CDNF illustrates the broader endeavor to unlock new avenues for treatment in the fight against neurodegeneration, highlighting the importance of understanding neurotrophic factors in developing effective therapies.












