Analytical Data
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Gene name
CYR61
- Application
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Alternative Names
CYR61；CYR61；CCN family member 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00622
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Expression Region
25-381aa
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AA Sequence
TCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDCSKTQPCDHTK GLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQCTCI DGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMED QDGLLGKELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPL QGQKCIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQ PVYSSLKKGKKCSKTKKSPEPVRFTYAGCLSVKKYRPKYCGSCVDGRCCT PQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNCPHANEAAFPFYRLFN DIHKFRDVDDIEGRMDEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKD TLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNST YRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVY TLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLD SDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
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Molecular Weight
67 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Cysteine-rich angiogenic protein 61 (CYR61) is a matricellular protein belonging to the CCN family, which plays a pivotal role in various physiological and pathological processes, including cell proliferation, migration, and differentiation. Its involvement in angiogenesis, wound healing, and tissue repair has garnered significant research interest, particularly in the context of cancer, where CYR61 is often upregulated and associated with tumor progression and metastasis. Previous studies have demonstrated that CYR61 modulates key signaling pathways, including the integrin and growth factor receptor pathways, which underscores its potential as a therapeutic target. Researchers have focused on generating recombinant CYR61 protein to elucidate its biological functions and interactions at the molecular level. Such studies are crucial for understanding how CYR61 contributes to the tumor microenvironment and its potential role in developing targeted cancer therapies. Additionally, the availability of recombinant CYR61 enables the exploration of its structural properties, binding affinities, and the mechanism by which it influences cellular behaviors. This research can pave the way for novel interventions aimed at inhibiting or modifying CYR61's activity in pathological conditions, thereby providing insights into its utility as a biomarker and therapeutic target in cancer treatment.
