Analytical Data
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Gene name
HTR3E
- Application
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Alternative Names
HTR3E；5-hydroxytryptamine receptor 3E
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
A5X5Y0
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Expression Region
72-229aa
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AA Sequence
MSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMSMAAKNLWLPDIFIIELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSRVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTSGTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVELWLQFSHAMDAMLFRLYLLFMASSIITVICLWNT
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Molecular Weight
58.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HTR3E, or 5-hydroxytryptamine receptor 3E, is a member of the serotonin receptor family, which plays a pivotal role in neurotransmission and has significant implications for various neurological and psychiatric disorders. This receptor is predominantly expressed in the central nervous system and is known to be involved in processes such as mood regulation, anxiety, and gastrointestinal function. Recent studies have highlighted the importance of HTR3E in modulating the effects of serotonin, a key neurotransmitter implicated in mood and behavior. The interest in HTR3E has surged due to its potential as a therapeutic target for conditions like depression, anxiety disorders, and irritable bowel syndrome. However, the structural and functional characterization of the HTR3E protein remains limited, hampering our understanding of its mechanisms. To address this gap, researchers are focused on the recombinant expression of the HTR3E protein. By utilizing various expression systems, scientists aim to produce HTR3E in sufficient quantities for functional assays, structural studies, and screening for potential pharmacological agents. Through these efforts, a clearer picture of HTR3E's role in serotonin signaling can emerge, paving the way for novel therapeutic strategies aimed at modulating its activity for clinical benefit. The ongoing research is critical not only for advancing knowledge in neurobiology but also for developing targeted treatments that could alleviate the burden of serotonin-related disorders.
