Analytical Data
-
Gene name
PTCD2
- Application
-
Alternative Names
Pentatricopeptide repeat domain 2; Pentatricopeptide repeat-containing protein 2; Pentatricopeptide repeat-containing protein 2 mitochondrial; Ptcd2; PTCD2_HUMAN
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q8WV60
-
Expression Region
1-388 aa
-
AA Sequence
MVRDSMAAAF RPSNRVLLQA LQILVYPGVG GSGSVSCRCP LGAKRYLLTD NVVKLKEFQQ KKVAVACNLS GTKETYFRNL KKKLTQNKLI LKGELITLLH LCESRDHVEL AKNVIYRYHA ENKNFTLGEY KFGPLFVRLC YELDLEESAV ELMKDQHLRG FFSDSTSFNI LMDMLFIKGK YKSALQVLIE MKNQDVKFTK DTYVLAFAIC YKLNSPESFK ICTTLREEAL LKGEILSRRA SCFAVALALN QNEMAKAVSI FSQIMNPESI ACINLNIIIH IQSNMLENLI KTLKNAAEGN LSKFVKRHVF SEEVLAKVRE KVKDVPALVA KFDEIYGTLH ITGQVTTDSL DAVLCHTPRD RKSHTLLLNK RMVSRRTFQP LSQSLLAE
-
Molecular Weight
43.9 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PTCD2, or Pentatricopeptide repeat-containing protein 2, is a crucial protein involved in post-transcriptional regulation of mitochondrial gene expression. Recent studies have highlighted its role in mitochondrial function, as it is implicated in the editing and regulation of mitochondrial RNA, which is vital for proper mitochondrial protein synthesis. Mitochondria are the powerhouses of the cell, and any dysfunction in their genetic regulation can lead to a variety of metabolic disorders and mitochondrial diseases. Understanding PTCD2's structure and function is essential for elucidating the mechanisms of mitochondrial gene expression and its implications in health and disease. The recombinant expression of PTCD2 allows researchers to investigate its biochemical properties, interaction with RNA, and potential as a therapeutic target. Additionally, studying PTCD2 can enhance our understanding of the molecular pathways involved in mitochondrial biogenesis and dynamics, which are critical for maintaining cellular energy homeostasis. With mitochondria being central to numerous physiological processes, insights gained from PTCD2 research may pave the way for novel strategies in treating mitochondrial-related diseases, making it a significant focus in contemporary molecular biology and therapeutic development.
