Analytical Data
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基因名
SLFN11
- Application
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别名
SLFN11；Schlafen family member 11
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q7Z7L1
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表达区间
345-901aa
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氨基酸序列
EKWVGMMTDTDPDLLQLSEDFECQLSLSSGPPLSRPVYSKKGLEHKKELQQLLFSVPPGYLRYTPESLWRDLISEHRGLEELINKQMQPFFRGILIFSRSWAVDLNLQEKPGVICDALLIAQNSTPILYTILREQDAEGQDYCTRTAFTLKQKLVNMGGYTGKVCVRAKVLCLSPESSAEALEAAVSPMDYPASYSLAGTQHMEALLQSLVIVLLGFRSLLSDQLGCEVLNLLTAQQYEIFSRSLRKNRELFVHGLPGSGKTIMAMKIMEKIRNVFHCEAHRILYVCENQPLRNFISDRNICRAETRKTFLRENFEHIQHIVIDEAQNFRTEDGDWYGKAKSITRRAKGGPGILWIFLDYFQTSHLDCSGLPPLSDQYPREELTRIVRNADPIAKYLQKEMQVIRSNPSFNIPTGCLEVFPEAEWSQGVQGTLRIKKYLTVEQIMTCVADTCRRFFDRGYSPKDVAVLVSTAKEVEHYKYELLKAMRKKRVVQLSDACDMLGDHIVLDSVRRFSGLERSIVFGIHPRTADPAILPNVLICLASRAKQHLYIFPWGGH
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分子量
69.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLFN11 (Sleep Latency Factor 11) is a member of the Schlafen protein family, known for its role in regulating cellular processes such as cell cycle progression and response to stress. Recent studies have highlighted the significance of SLFN11 in cancer biology, particularly its potential as a biomarker for sensitivity to certain chemotherapeutic agents, including DNA damaging drugs. SLFN11 has been shown to inhibit the proliferation of cancer cells by interfering with their DNA repair mechanisms, making it a promising target for novel therapeutic strategies. Additionally, research indicates that the expression levels of SLFN11 can correlate with the effectiveness of treatment in various cancer types, suggesting its utility in personalized medicine approaches. As a result, the production of recombinant SLFN11 protein has gained attention, enabling researchers to further investigate its molecular functions and interactions in vitro and in vivo. Such studies aim to elucidate the precise mechanisms by which SLFN11 exerts its effects on cancer cell biology, facilitating the development of SLFN11-based therapies or combination treatments that could improve response rates in resistant cancer populations. Overall, the exploration of SLFN11 as a recombinantly expressed protein represents a crucial step towards understanding its role in tumor biology and its potential application in cancer treatment.
