Analytical Data
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Gene name
RAET1E
- Application
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Alternative Names
bA350J20.7; LETAL; Lymphocyte effector toxicity activation ligand; MGC125308; MGC125309; N2DL-4; N2DL4; N2DL4_HUMAN; NKG2D ligand 4; NKG2D ligand 4 precursor; NKG2DL4; RAE-1-like transcript 4; RAET1E; RAET1E2; Retinoic acid early transcript 1E; RL-4
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8TD07
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Expression Region
1-263 aa
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AA Sequence
MRRISLTSSPVRLLLFLLLLLIALEIMVGGHSLCFNFTIKSLSRPGQPWCEAQVFLNKNLFLQYNSDNNMVKPLGLLGKKVNATSTWGELTQTLGEVGRDLRMLLCDIKPQIKTSDPSTLQVEMFCQHEAERCTGASWQFTINGEKSLLFDAMNMTWTVINHEASKIKETWKKDRGLEKYFRKLSKGDCDHWLREFLGHWEAMPEPTVSPVNASDIHWSSSSLPDRWIILGAFILLLLMGIVLICVWWQNGEWQAGLWPLRTS
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Molecular Weight
56.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RAET1E, a member of the RAET (Retinoic Acid Early Transcript) family, is a protein implicated in various biological processes, particularly those related to immune responses. Expressed predominantly in immune cells, RAET1E plays a vital role in the regulation of natural killer (NK) cells, impacting their activation and function. Understanding RAET1E's structure and mechanism is critical, as it interacts with NKG2D receptors on NK cells, influencing their ability to recognize and eliminate tumor cells and infected cells. Research has demonstrated that RAET1E expression can be modulated in response to inflammatory stimuli, suggesting its potential as a therapeutic target in cancer and autoimmune diseases. Moreover, the study of RAET1E recombinant protein provides insights into its functional roles and interactions, paving the way for the development of novel immunotherapies. The ongoing investigations aim to characterize this protein further, delve into its role in immune evasion by tumors, and explore how manipulating RAET1E expression could enhance the efficacy of existing immunotherapeutic strategies. As a result, RAET1E has emerged as a promising candidate for advancing our understanding of immune regulation and improving therapeutic outcomes in various diseases.
