Analytical Data
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Gene name
C21orf66
- Application
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Alternative Names
PAX3- and PAX7-binding Protein 1. GC-rich sequence DNA-binding factor 1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y5B6
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Expression Region
1-398aa
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AA Sequence
MFRKARRVNVRKRNDSEEEERERDEEQEPPPLLPPPGTGEEAGPGGGDRAPGGESLLGPGPSPPSALTPGLGAEAGGGFPGGAEPGNGLKPRKRPRENKEVPRASLLSFQDEEEENEEVFKVKKSSYSKKIVKLLKKEYKEDLEKSKIKTELNSSAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMESEKEEEKPKTGGAFSNALSSLNVLRPGEIPDAAFIHAARKKRQMARELGDFTPHDNEPGKGRLVREDENDASDDEDDDEKRRIVFSVKEKSQRQKIAEEIGIEGSDDDALVTGEQDEELSRWEQEQIRKGINIPQVQASQPAEVNMYYQNTYQTMPYGSSYGIPYSYTAYGSSDAKSQKTDNTVPFKTPSNEMTPVTIDLVKKQLKDR
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Molecular Weight
70.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
C21orf66, also known as Chromosome 21 Open Reading Frame 66, is a gene located on chromosome 21 and has garnered interest in the scientific community due to its potential role in cellular processes and disease mechanisms. Research indicates that C21orf66 may be involved in various physiological functions, including cell signaling, proliferation, and apoptosis, with implications for understanding conditions such as Down syndrome and other genetic disorders. The protein encoded by C21orf66 is still not fully characterized, making it a compelling subject for further investigation. Recent studies have aimed at the recombinant expression of C21orf66 to elucidate its structure and function, employing techniques such as molecular cloning and protein purification. By studying the recombinant C21orf66 protein, researchers hope to uncover its biological activities, interactions with other cellular proteins, and its overall impact on cellular homeostasis. Such insights could pave the way for novel therapeutic strategies targeting C21orf66-related pathways in disease contexts. Additionally, the recombinant protein can serve as a valuable tool for developing diagnostic assays or experimental models, contributing to a deeper understanding of the implications of chromosome 21 anomalies in human health. Overall, the investigation of C21orf66 serves as a critical endeavor in elucidating the complex genetic landscape associated with chromosome 21 and its links to various pathologies.
