Analytical Data
-
Gene name
CABP4
- Application
-
Alternative Names
CABP4; Calcium-binding Protein 4; CaBP4
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P57796
-
Expression Region
1-275aa
-
AA Sequence
MTTEQARGQQ GPNLAIGRQK PPAGVVTPKS DAEEPPLTRK RSKKERGLRG SRKRTGSSGE QTGPEAPGSS NNPPSTGEGP AGAPPASPGP ASSRQSHRHR PDSLHDAAQR TYGPLLNRVF GKDRELGPEE LDELQAAFEE FDTDRDGYIS HRELGDCMRT LGYMPTEMEL LEVSQHIKMR MGGRVDFEEF VELIGPKLRE ETAHMLGVRE LRIAFREFDR DRDGRITVAE LREAVPALLG EPLAGPELDE MLREVDLNGD GTVDFDEFVM MLSRH
-
Molecular Weight
30.4 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CABP4, or Calcium-Binding Protein 4, is part of the prevalent family of calcium-binding proteins, playing a crucial role in calcium signaling pathways within various tissues, particularly in the nervous system. Research has highlighted its implications in synaptic transmission and plasticity, linking CABP4 to neurological functions and potential neurodevelopmental disorders. The protein is known to modulate the activity of voltage-gated calcium channels, thereby influencing neurotransmitter release and neuronal excitability. Given the significance of CABP4 in clinical conditions, such as autism spectrum disorders and other neurodevelopmental issues, understanding its structure and function is essential for unraveling its role in cellular processes. The production of recombinant CABP4 protein has become a focal point of research efforts to elucidate its biochemical properties, interactions, and regulatory mechanisms. This recombinant approach allows for detailed studies on the protein's functional characteristics, its binding affinity for calcium ions, and its effects on calcium channel modulation. By employing techniques such as X-ray crystallography and NMR spectroscopy, researchers aim to define the molecular architecture of CABP4 and how it integrates into larger signaling networks. The insights gained from CABP4 research possess the potential to inform therapeutic strategies targeting neurological conditions and enhance our comprehension of calcium signaling in health and disease. Ultimately, CABP4 represents a crucial entity in the intersection of cellular biology, neurobiology, and therapeutic development, making it an important subject of ongoing scientific inquiry.
