Analytical Data
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基因名
REPS2
- Application
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别名
REPS2; POB1; RalBP1-associated Eps domain-containing protein 2; Partner of RalBP1; RalBP1-interacting protein 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NFH8
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表达区间
1-660 aa
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氨基酸序列
MEAAAAAAAA AAAAAAAGGG CGSGPPPLLL SEGEQQCYSE LFARCAGAAG GGPGSGPPEA ARVAPGTATA AAGPVADLFR ASQLPAETLH QITELCGAKR VGYFGPTQFY IALKLIAAAQ SGLPVRIESI KCELPLPRFM MSKNDGEIRF GNPAELHGTK VQIPYLTTEK NSFKRMDDED KQQETQSPTM SPLASPPSSP PHYQRVPLSH GYSKLRSSAE QMHPAPYEAR QPLVQPEGSS SGGPGTKPLR HQASLIRSFS VERELQDNSS YPDEPWRITE EQREYYVNQF RSLQPDPSSF ISGSVAKNFF TKSKLSIPEL SYIWELSDAD CDGALTLPEF CAAFHLIVAR KNGYPLPEGL PPTLQPEYLQ AAFPKPKWDC QLFDSYSESL PANQQPRDLN RMEKTSVKDM ADLPVPNQDV TSDDKQALKS TINEALPKDV SEDPATPKDS NSLKARPRSR SYSSTSIEEA MKRGEDPPTP PPRPQKTHSR ASSLDLNKVF QPSVPATKSG LLPPPPALPP RPCPSQSEQV SEAELLPQLS RAPSQAAESS PAKKDVLYSQ PPSKPIRRKF RPENQATENQ EPSTAASGPA SAATMKPHPT VQKQSSKQKK AIQTAIRKNK EANAVLARLN SELQQQLKEV HQERIALENQ LEQLRPVTVL
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分子量
71.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
REPS2 (Regulator of G-Protein Signaling 2) is a member of the REPS family, which plays a crucial role in various cellular processes, including signal transduction and endocytosis. Research on REPS2 has gained momentum due to its involvement in modulating G-protein signaling pathways, which are integral to many physiological functions. Dysregulation of these pathways can lead to several diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. Recent studies have highlighted the importance of REPS2 in regulating the recycling and degradation of G-protein-coupled receptors (GPCRs), making it a potential target for therapeutic interventions. Additionally, REPS2 is implicated in the endosomal trafficking of signaling molecules, thereby influencing cellular responses to extracellular stimuli. Understanding the molecular mechanisms governing REPS2's function and its interactions with various signaling partners could provide valuable insights into the intricate network of intracellular signaling. This knowledge may ultimately lead to the development of novel strategies for treating disorders linked to G-protein signaling dysregulation, underscoring the significance of REPS2 as a subject of ongoing scientific inquiry.
