Analytical Data
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Gene name
CENPL
- Application
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Alternative Names
CENPL; C1orf155; ICEN33; Centromere Protein L; CENP-L; Interphase centromere complex Protein 33
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N0S6
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Expression Region
1-390aa
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AA Sequence
MDSYSAPESTPSASSRPEDYFIGATPLQKRLESVRKQSSFILTPPRRKIPQCSQLQEDVDPQKVAFLLHKQWTLYSLTPLYKFSYSNLKEYSRLLNAFIVAEKQKGLAVEVGEDFNIKVIFSTLLGMKGTQRDPEAFLVQGLILSPRLEYSGTILVDCNLCLLGSSDPSTLAFQVAGTAGACHHTRIVSKSQLPSENREGKVLWTGWFCCVFGDSLLETVSEDFTCLPLFLANGAESNTAIIGTWFQKTFDCYFSPLAINAFNLSWMAAMWTACKMDHYVATTEFLWSVPCSPQSLDISFAIHPEDAKALWDSVHKTPGEVTQEEVDLFMDCLYSHFHRHFKIHLSATRLVRVSTSVASAHTDGKIKILCHKYLIGVLAYLTELAIFQIE
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Molecular Weight
70.1 KDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CENPL, or Centromere Protein L, is a crucial component of the centromere and plays a significant role in chromosome segregation during cell division. As a member of the CENP family, CENPL is involved in the formation and maintenance of the centromere structure, ensuring accurate mitosis and meiosis. Dysregulation of CENPL has been linked to various human diseases, including cancer, highlighting its importance in maintaining genomic stability. Research into the recombinant expression of CENPL offers valuable insights into its functional dynamics and interactions with other centromeric proteins. By producing CENPL in vitro using recombinant DNA technology, scientists can study its biochemical properties, structural characteristics, and role in the assembly of the centromere complex. These investigations not only enhance our understanding of fundamental cellular processes but also pave the way for potential therapeutic applications targeting cell division errors associated with diseases. The detailed study of CENPL may also contribute to the development of strategies for cancer treatment by identifying novel targets for intervention. Overall, the research on CENPL recombinant proteins is essential for elucidating the mechanisms underlying chromosome behavior and their implications for human health.
