Analytical Data
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基因名
CENPC1
- Application
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别名
Centromere Protein C. CENP-C. Centromere autoantigen C. Centromere Protein C 1. CENP-C 1. Interphase centromere complex Protein 7
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q03188
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表达区间
1-542aa
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氨基酸序列
MAASGLDHLKNGYRRRFCRPSRARDINTEQGQNVLEILQDCFEEKSLANDFSTNSTKSVPNSTRKIKDTCIQSPSKECQKSHPKSVPVSSKKKEASLQFVVEPSEATNRSVQAHEVHQKILATDVSSKNTPDSKKISSRNINDHHSEADEEFYLSVGSPSVLLDAKTSVSQNVIPSSAQKRETYTFENSVNMLPSSTEVSVKTKKRLNFDDKVMLKKIEIDNKVSDEEDKTSEGQERKPSGSSQNRIRDSEYEIQRQAKKSFSTLFLETVKRKSESSPIVRHAATAPPHSCPPDDTKLIEDEFIIDESDQSFASRSWITIPRKAGSLKQRTISPAESTALLQGRKSREKHHNILPKTLANDKHSHKPHPVETSQPSDKTVLDTSYALIGETVNNYRSTKYEMYSKNAEKPSRSKRTIKQKQRRKFMAKPAEEQLDVGQSKDENIHTSHITQDEFQRNSDRNMEEHEEMGNDCVSKKQMPPVGSKKSSTRKDKEESKKKRFSSESKNKLVPEEVTSTVTKSRRISRRPSDWWVVKSEESCLKC
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分子量
87.9 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CENPC1, also known as centromere protein C1, is a crucial component of the centromere structure, which plays a vital role in chromosome segregation during cell division. Aberrations in centromere function can lead to chromosomal instability, a hallmark of many cancers and genetic disorders. Research on CENPC1 has gained momentum due to its importance in maintaining genome integrity and facilitating accurate mitotic processes. Understanding the molecular mechanisms by which CENPC1 contributes to centromere function and chromosomal organization is essential for elucidating the etiology of diseases linked to chromosomal abnormalities. Advances in recombinant protein technology have enabled the production of CENPC1 in vitro, allowing for in-depth biochemical and biophysical studies to explore its interactions with other centromeric proteins and its role within the kinetochore complex. These studies not only contribute to the fundamental understanding of centromere biology but may also reveal potential therapeutic targets for cancer treatment, as manipulation of CENPC1 activity could influence cell proliferation and survival. Overall, the investigation of CENPC1 and its associated pathways is vital for developing strategies to combat diseases associated with chromosomal instability.
