Analytical Data
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基因名
HPX
- Application
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别名
HPX；Hemopexin
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P02790
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表达区间
24-462aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSTPLPPTSAHGNVAEGETKPDPDVTERC SDGWSFDATTLDDNGTMLFFKGEFVWKSHKWDRELISERWKNFPSPVDAA FRQGHNSVFLIKGDKVWVYPPEKKEKGYPKLLQDEFPGIPSPLDAAVECH RGECQAEGVLFFQGDREWFWDLATGTMKERSWPAVGNCSSALRWLGRYYC FQGNQFLRFDPVRGEVPPRYPRDVRDYFMPCPGRGHGHRNGTGHGNSTHH GPEYMRCSPHLVLSALTSDNHGATYAFSGTHYWRLDTSRDGWHSWPIAHQ WPQGPSAVDAAFSWEEKLYLVQGTQVYVFLTKGGYTLVSGYPKRLEKEVG TPHGIILDSVDAAFICPGSSRLHIMAGRRLWWLDLKSGAQATWTELPWPH EKVDGALCMEKSLGPNSCSANGPGLYLIHGPNLYCYSDVEKLNAAKALPQ PQNVTSLLGCTH
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分子量
52 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HPX, or Hemopexin, is a glycoprotein that plays a critical role in the body's response to oxidative stress and inflammation. It is primarily produced by the liver and is involved in heme scavenging, binding free heme released from hemoglobin, and facilitating its clearance from circulation. Research into HPX recombinant proteins has gained significance due to their potential therapeutic applications, particularly in conditions characterized by heme toxicity, such as hemolytic anemia, sickle cell disease, and other disorders where excess free heme can lead to oxidative damage and inflammation. The ability to produce HPX recombinantly allows for a more abundant and purified source for investigational studies, enabling researchers to explore its biological functions, mechanisms of action, and therapeutic efficacy. Additionally, recombinant HPX can serve as a valuable tool in deciphering the intricacies of heme metabolism and the inflammatory responses associated with various diseases. Overall, the investigation of recombinant HPX highlights its importance in both basic and translational research, offering insights into new treatment strategies for heme-related pathologies.
