Analytical Data
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Gene name
SCDR10
- Application
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Alternative Names
HSD11B1L; HSD3; SCDR10; SDR26C2Hydroxysteroid 11-beta-dehydrogenase 1-like protein; EC 1.1.1.-; 11-beta-hydroxysteroid dehydrogenase type 3; 11-DH3; 11-beta-HSD3; Short chain dehydrogenase/reductase family 26C member 2; Short-chain dehydrogenase/reductase 10
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q7Z5J1
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Expression Region
16-315 aa
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AA Sequence
YYWDD NFDPASLQGA RVLLTGANAG VGEELAYHYA RLGSHLVLTA HTEALLQKVV GNCRKLGAPK VFYIAADMAS PEAPESVVQF ALDKLGGLDY LVLNHIGGAP AGTRARSPQA TRWLMQVNFV SYVQLTSRAL PSLTDSKGSL VVVSSLLGRV PTSFSTPYSA AKFALDGFFG SLRRELDVQD VNVAITMCVL GLRDRASAAE AVRSSTSRPR QPEHRGVPLQ SQTAMFLPPT VPGARTLTET PLRGWPQPKM KSSRQKSKTE KNDGHLEPVT AWEVQVPRVR RLCRGLARPH LFGHD
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Molecular Weight
34.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SCDR10, or Siderocalin-like protein 10, is a novel recombinant protein that has garnered attention due to its potential roles in iron homeostasis and immune response. Iron is essential for various biological processes, but its free form can be toxic, necessitating tight regulation in the body. Recent studies have highlighted the role of SCDR10 in modulating iron availability in physiological and pathological contexts, such as infections and inflammation. Disturbances in iron metabolism have been implicated in several diseases, including anemia, neurodegenerative disorders, and cancer. This positions SCDR10 as a critical player in both health and disease, prompting researchers to explore its structure, function, and therapeutic potential. The recombinant production of SCDR10 allows for detailed investigations into its biochemical properties and interactions, aiding in the elucidation of its mechanisms of action. Understanding SCDR10's role may pave the way for novel therapeutic strategies targeting iron-related dysfunctions and improve outcomes in diseases where iron dysregulation is a contributing factor. As such, the study of SCDR10 is a promising area of research with implications for enhancing the comprehension of iron metabolism and developing innovative treatments.
