Analytical Data
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基因名
SCAP2
- Application
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别名
Src kinase-associated phosphoprotein 2. Pyk2/RAFTK-associated protein. Retinoic acid-induced protein 70. SKAP55 homolog. SKAP-55HOM. SKAP-HOM. Src family-associated phosphoprotein 2. Src kinase-associated phosphoprotein 55-related protein. Src-associated adapter protein with PH and SH3 domains
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75563
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表达区间
1-359 aa
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氨基酸序列
MPNPSSTSSPYPLPEEIRNLLADVETFVADILKGENLSKKAKEKRESLIKKIKDVKSIYLQEFQDKGDAEDGEEYDDPFAGPPDTISLASERYDKDDEAPSDGAQFPPIAAQDLPFVLKAGYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNTLRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIPEDYDERGELYDDVDHPLPISNPLTSSQPIDDEIYEELPEEEEDSAPVKVEEQRKMSQDSVHHTSGDKSTDYANFYQGLWDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYIMEMYDI
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分子量
65.23 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SCAP2 (SREBP cleavage-activating protein 2) is a crucial component of the sterol regulatory element-binding protein (SREBP) pathway, which plays an essential role in lipid metabolism and cellular cholesterol homeostasis. Recent studies have highlighted the importance of SCAP2 in regulating the activation of SREBP, a transcription factor that modulates the expression of various genes involved in cholesterol and fatty acid synthesis. Abnormal functioning of the SREBP pathway is associated with metabolic disorders such as obesity, insulin resistance, and cardiovascular diseases. As SCAP2 is fundamental in bridging the cellular lipid sensing with gene regulation, the characterization of SCAP2 recombinant protein has become an important focus in biochemical research. By producing SCAP2 as a recombinant protein, researchers aim to study its structure, function, and interactions with other cellular components in detail. This research could facilitate the identification of therapeutic targets and the development of novel strategies to combat metabolic diseases. Understanding the mechanistic role of SCAP2 in the SREBP pathway may provide insights into potential interventions that could restore normal lipid metabolism and prevent the progression of associated disorders. As such, SCAP2 serves as a promising avenue for advancements in biomedical research and the development of innovative treatments for metabolic syndromes.
