Analytical Data
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Gene name
SCFD1
- Application
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Alternative Names
C14orf163; Chromosome 14 open reading frame 163; RA410; Scfd1; SCFD1_HUMAN; Sec1 family domain containing 1; Sec1 family domain-containing protein 1; SLY1; SLY1 homolog; Sly1p; STXBP1L2; Syntaxin binding protein 1 like 2; Syntaxin-binding protein 1-like 2; Vesicle transport related protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8WVM8
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Expression Region
2-642 aa
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AA Sequence
AAAAAATAA AAASIRERQT VALKRMLNFN VPHIKNSTGE PVWKVLIYDR FGQDIISPLL SVKELRDMGI TLHLLLHSDR DPIPDVPAVY FVMPTEENID RMCQDLRNQL YESYYLNFIS AISRSKLEDI ANAALAASAV TQVAKVFDQY LNFITLEDDM FVLCNQNKEL VSYRAINRPD ITDTEMETVM DTIVDSLFCF FVTLGAVPII RCSRGTAAEM VAVKLDKKLR ENLRDARNSL FTGDTLGAGQ FSFQRPLLVL VDRNIDLATP LHHTWTYQAL VHDVLDFHLN RVNLEESSGV ENSPAGARPK RKNKKSYDLT PVDKFWQKHK GSPFPEVAES VQQELESYRA QEDEVKRLKS IMGLEGEDEG AISMLSDNTA KLTSAVSSLP ELLEKKRLID LHTNVATAVL EHIKARKLDV YFEYEEKIMS KTTLDKSLLD IISDPDAGTP EDKMRLFLIY YISTQQAPSE ADLEQYKKAL TDAGCNLNPL QYIKQWKAFT KMASAPASYG STTTKPMGLL SRVMNTGSQF VMEGVKNLVL KQQNLPVTRI LDNLMEMKSN PETDDYRYFD PKMLRGNDSS VPRNKNPFQE AIVFVVGGGN YIEYQNLVDY IKGKQGKHIL YGCSELFNAT QFIKQLSQLG QK
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Molecular Weight
72.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SCFD1 (S-phase Cyclin-F-Dependent Kinase) is a crucial protein involved in various cellular processes, particularly in the regulation of the cell cycle and DNA repair mechanisms. Its role in the ubiquitin-proteasome system is essential for maintaining protein homeostasis, impacting numerous signaling pathways that govern cell proliferation and apoptosis. Recent studies have highlighted its involvement in cancer biology, as aberrations in SCFD1 expression or function can lead to uncontrolled cell growth and tumorigenesis. Additionally, SCFD1 is implicated in the response to DNA damage, where it collaborates with other proteins to facilitate repair processes, ensuring genomic stability. This makes SCFD1 a target of interest for therapeutic intervention in cancer and other diseases characterized by cell cycle dysregulation. Understanding the structure-function relationship of SCFD1 through recombinant protein studies can provide insights into its molecular mechanisms and enhance the development of novel strategies aimed at modulating its activity for clinical applications. As research progresses, SCFD1's potential as a biomarker for cancer prognosis and a target for drug development becomes increasingly significant, underscoring the importance of comprehensively studying this protein in cell biology and oncology.
