Analytical Data
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基因名
TMOD4
- Application
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别名
TMOD4；Tropomodulin-4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NZQ9
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表达区间
1-345aa
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氨基酸序列
MSSYQKELEKYRDIDEDEILRTLSPEELEQLDCELQEMDPENMLLPAGLRQRDQTKKSPTGPLDREALLQYLEQQALEVKERDDLVPFTGEKKGKPYIQPKREIPAEEQITLEPELEEALAHATDAEMCDIAAILDMYTLMSNKQYYDALCSGEICNTEGISSVVQPDKYKPVPDEPPNPTNIEEILKRVRSNDKELEEVNLNNIQDIPIPMLSELCEAMKANTYVRSFSLVATRSGDPIANAVADMLRENRSLQSLNIESNFISSTGLMAVLKAVRENATLTELRVDNQRQWPGDAVEMEMATVLEQCPSIVRFGYHFTQQGPRARAAQAMTRNNELRRQQKKR
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分子量
66.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TMOD4, or tropomodulin 4, is a member of the tropomodulin family, which plays a crucial role in regulating actin filament dynamics and stabilization in muscle and non-muscle cells. Research into TMOD4 has gained importance due to its potential involvement in various cellular processes, including muscle development, cell motility, and the maintenance of cellular shape. Unlike other tropomodulin isoforms, TMOD4 is predominantly expressed in the heart and brain, indicating its specialized functions in these tissues. Recent studies have focused on the structural and functional characterization of recombinant TMOD4 proteins, exploring their interactions with actin filaments and other cytoskeletal components. This research not only aids in understanding the molecular mechanics of TMOD4 but also opens avenues for exploring its implications in cardiac and neurological disorders. By generating and analyzing TMOD4 recombinant proteins, researchers aim to elucidate its regulatory mechanisms and potential as a therapeutic target in diseases associated with abnormal actin dynamics. Understanding TMOD4's role in the actin cytoskeleton is pivotal for advancing our knowledge of cellular architecture and function, as well as for the development of novel treatment strategies for conditions linked to actin filament anomalies.
