Analytical Data
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基因名
CLK1
- Application
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别名
CDC like kinase 1; CDC-like kinase 1; CDC28/CDC2 like kinase; CLK; CLK/STY; Clk1; CLK1_HUMAN; Dual specificity protein kinase CLK1; Protein tyrosine kinase STY; STY
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P49759
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表达区间
1-484aa
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氨基酸序列
MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSK MCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNH SSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLI CQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYC EAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYD FIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSD YTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEV ILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPK HMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERL FDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI
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分子量
79 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CLK1 (Clock-Associated Protein 1) is a pivotal component in the regulation of circadian rhythms, which are critical for maintaining physiological homeostasis in various biological processes. The protein is encoded by the CLK1 gene, which has been linked to the development of several diseases, including neurodegenerative disorders and metabolic syndromes. Research has shown that CLK1 is involved in modulating the circadian clock by affecting the expression of core clock genes, thus playing a significant role in the synchronization of biological processes with the external environment. Furthermore, CLK1 has gained attention for its potential as a therapeutic target. For instance, its inhibition has been explored as a strategy for cancer treatment, given its influence on cell proliferation and apoptosis in cancerous cells. Recent studies employing recombinant CLK1 protein have sought to elucidate its structure and function further, aiming to understand how it interacts with other molecular components within the circadian clock network. These insights could pave the way for novel drug development and innovative approaches in treating diseases associated with circadian misalignment. The exploration of CLK1 as a recombinant protein not only enhances our fundamental understanding of circadian biology but also presents opportunities for translating this knowledge into clinical applications, promoting better health outcomes through the manipulation of circadian rhythms. Thus, the study of CLK1 continues to be a vibrant field of research, bridging molecular biology, pharmacology, and clinical medicine in the quest to harness the power of our biological clocks.
