Analytical Data
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Gene name
COG2
- Application
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Alternative Names
Brefeldin A sensitive peripheral Golgi protein; CDG2Q; COG 2; COG complex subunit 2; COG2; COG2_HUMAN; Component of oligomeric Golgi complex 2; Conserved oligomeric Golgi complex component 2; Conserved oligomeric Golgi complex subunit 2
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14746
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Expression Region
1-738aa
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AA Sequence
MEKSRMNLPKGPDTLCFDKDEFMKEDFDVDHFVSDCRKRVQLEELRDDLELYYKLLKTAMVELINKDYADFVNLSTNLVGMDKALNQLSVPLGQLREEVLSLRSSVSEGIRAVDERMSKQEDIRKKKMCVLRLIQVIRSVEKIEKILNSQSSKETSALEASSPLLTGQILERIATEFNQLQFHAVQSKGMPLLDKVRPRIAGITAMLQQSLEGLLLEGLQTSDVDIIRHCLRTYATIDKTRDAEALVGQVLVKPYIDEVIIEQFVESHPNGLQVMYNKLLEFVPHHCRLLREVTGGAISSEKGNTVPGYDFLVNSVWPQIVQGLEEKLPSLFNPGNPDAFHEKYTISMDFVRRLERQCGSQASVKRLRAHPAYHSFNKKWNLPVYFQIRFREIAGSLEAALTDVLEDAPAESPYCLLASHRTWSSLRRCWSDEMFLPLLVHRLWRLTLQILARYSVFVNELSLRPISNESPKEIKKPLVTGSKEPSITQGNTEDQGSGPSETKPVVSISRTQLVYVVADLDKLQEQLPELLEIIKPKLEMIGFKNFSSISAALEDSQSSFSACVPSLSSKIIQDLSDSCFGFLKSALEVPRLYRRTNKEVPTTASSYVDSALKPLFQLQSGHKDKLKQAIIQQWLEGTLSESTHKYYETVSDVLNSVKKMEESLKRLKQARKTTPANPVGPSGGMSDDDKIRLQLALDVEYLGEQIQKLGLQASDIKSFSALAELVAAAKDQATAEQP
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Molecular Weight
107.58 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
COG2, a member of the conserved oligomeric Golgi (COG) complex, plays a critical role in intracellular membrane trafficking and maintaining Golgi structure and function. The COG complex is essential for proper glycosylation of proteins and lipids, influencing various cellular processes, including secretion, signal transduction, and cell adhesion. Mutations or dysfunctions in COG2 have been linked to several human diseases, particularly congenital disorders related to glycosylation, which can lead to severe developmental and functional abnormalities. Researchers are increasingly focused on the study of COG2 recombinant protein to understand its precise molecular mechanisms and interactions within the COG complex. By producing COG2 as a recombinant protein, scientists aim to elucidate its role in Golgi dynamics, identify binding partners, and develop therapeutic strategies to address COG-related disorders. The ability to generate high-purity recombinant COG2 facilitates in vitro studies that may reveal the structural and functional properties of this protein, further shedding light on its contribution to cellular homeostasis and the pathogenesis of associated diseases. Therefore, research on COG2 not only enhances our understanding of fundamental cellular processes but also holds potential for informing the development of innovative treatments for glycosylation disorders.
