Analytical Data
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基因名
BAG3
- Application
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别名
BAG3；BIS；BAG family molecular chaperone regulator 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95817
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表达区间
1-575aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MSAATHSPMM QVASGNGDRD PLPPGWEIKI DPQTGWPFFV DHNSRTTTWN DPRVPSEGPK ETPSSANGPS REGSRLPPAR EGHPVYPQLR PGYIPIPVLH EGAENRQVHP FHVYPQPGMQ RFRTEAAAAA PQRSQSPLRG MPETTQPDKQ CGQVAAAAAA QPPASHGPER SQSPAASDCS SSSSSASLPS SGRSSLGSHQ LPRGYISIPV IHEQNVTRPA AQPSFHQAQK THYPAQQGEY QTHQPVYHKI QGDDWEPRPL RAASPFRSSV QGASSREGSP ARSSTPLHSP SPIRVHTVVD RPQQPMTHRE TAPVSQPENK PESKPGPVGP ELPPGHIPIQ VIRKEVDSKP VSQKPPPPSE KVEVKVPPAP VPCPPPSPGP SAVPSSPKSV ATEERAAPST APAEATPPKP GEAEAPPKHP GVLKVEAILE KVQGLEQAVD NFEGKKTDKK YLMIEEYLTK ELLALDSVDP EGRADVRQAR RDGVRKVQTI LEKLEQKAID VPGQVQVYEL QPSNLEADQP LQAIMEMGAV AADKGKKNAG NAEDPHTETQ QPEATAAATS NPSSMTDTPG NPAAP
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BAG3 is a member of the BCL-2-associated athanogene (BAG) protein family, which plays a crucial role in various cellular processes, including protein homeostasis, apoptosis, and stress response. Research on BAG3 has gained significant attention due to its involvement in multiple diseases, including cancer, neurodegenerative disorders, and muscle wasting conditions. In cancer, BAG3 functions as an anti-apoptotic factor, promoting cell survival by inhibiting programmed cell death, thus facilitating tumor progression and resistance to therapies. In neurodegenerative diseases, BAG3 is implicated in the modulation of protein aggregation and autophagy, processes that are critical for neuronal health. Additionally, its role in muscle cells suggests that BAG3 may influence myofibrillar myopathy, highlighting its potential as a therapeutic target. Recent studies have focused on the structural and functional characterization of BAG3, aiming to elucidate its biochemical pathways and interactions with other proteins. Understanding BAG3 interactions at the molecular level could provide insights into its dual role as a promoter of cell survival and a regulator of autophagy, opening new avenues for drug development and therapeutic interventions in diseases associated with BAG3 dysregulation. Overall, the comprehensive study of BAG3 and its restructured protein forms holds promise for advancing our knowledge of cellular stress responses and may lead to novel strategies for treating BAG3-related conditions.
