Analytical Data
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基因名
DDX17
- Application
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别名
Ddx17; DDX17_HUMAN; DEAD (Asp Glu Ala Asp) box helicase 17; DEAD (Asp Glu Ala Asp) box polypeptide 17 ; DEAD box helicase 17; DEAD box protein 17; DEAD box protein p72; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 17; P72; Probable ATP-dependent RNA helicase DDX17; RH70
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92841
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表达区间
1-729aa
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氨基酸序列
MPTGFVAPIL CVLLPSPTRE AATVASATGD SASERESAAP AAAPTAEAPP PSVVTRPEPQ ALPSPAIRAP LPDLYPFGTM RGGGFGDRDR DRDRGGFGAR GGGGLPPKKF GNPGERLRKK KWDLSELPKF EKNFYVEHPE VARLTPYEVD ELRRKKEITV RGGDVCPKPV FAFHHANFPQ YVMDVLMDQH FTEPTPIQCQ GFPLALSGRD MVGIAQTGSG KTLAYLLPAI VHINHQPYLE RGDGPICLVL APTRELAQQV QQVADDYGKC SRLKSTCIYG GAPKGPQIRD LERGVEICIA TPGRLIDFLE SGKTNLRRCT YLVLDEADRM LDMGFEPQIR KIVDQIRPDR QTLMWSATWP KEVRQLAEDF LRDYTQINVG NLELSANHNI LQIVDVCMES EKDHKLIQLM EEIMAEKENK TIIFVETKRR CDDLTRRMRR DGWPAMCIHG DKSQPERDWV LNEFRSGKAP ILIATDVASR GLDVEDVKFV INYDYPNSSE DYVHRIGRTA RSTNKGTAYT FFTPGNLKQA RELIKVLEEA NQAINPKLMQ LVDHRGGGGG GGGRSRYRTT SSANNPNLMY QDECDRRLRG VKDGGRRDSA SYRDRSETDR AGYANGSGYG SPNSAFGAQA GQYTYGQGTY GAAAYGTSSY TAQEYGAGTY GASSTTSTGR SSQSSSQQFS GIGRSGQQPQ PLMSQQFAQP PGATNMIGYM GQTAYQYPPP PPPPPPSRK
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分子量
80.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DDX17, a member of the DEAD-box RNA helicase family, plays a crucial role in various essential cellular processes, including RNA metabolism, splicing, and ribosome biogenesis. Research has highlighted the significance of DDX17 in cancer biology, where it serves as a potential oncogene, suggesting its involvement in the regulation of gene expression and cellular proliferation. Dysregulation of DDX17 has been implicated in several malignancies, making it a promising target for therapeutic intervention. Additionally, studies have demonstrated that DDX17 interacts with numerous RNA-binding proteins and splicing factors, influencing alternative splicing events that can contribute to tumorigenesis. The recombinant expression of DDX17 protein allows for detailed biochemical characterization, functional assays, and the exploration of its molecular interactions. Understanding the structure-function relationships of DDX17 through recombinant techniques is essential for elucidating its role in disease and can potentially lead to novel strategies for cancer treatment. This research not only highlights the potential of DDX17 as a biomarker for cancer diagnosis and prognosis but also underscores the importance of DEAD-box helicases in the regulation of gene expression networks critical for tumor biology. Thus, ongoing investigations into DDX17 as a recombinant protein offer valuable insights into its biological functions and therapeutic potential, representing a significant advancement in the field of molecular oncology.
